Discovery through Partnership | Excellence through Quality
| Product Name | Baricitinib |
| Description |
Kinase inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 1187594-09-7 |
| Molecular Formula | C16H17N7O2S |
| Molecular Weight | 371.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (30 mg/ml); or DMF (50 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white powder |
| SMILES | CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 |
| InChI | InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20) |
| InChIKey | XUZMWHLSFXCVMG-UHFFFAOYSA-N |
| Safety Phrases |
Hazard statements Harmful if swallowed. · Precautionary statements Wash thoroughly after handling. Do not eat, drink or smoke when using this product. |
| Cite This Product | Baricitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-587) |
Biological Description
| Alternative Names | 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile, INCB028050, LY3009104 |
| Research Areas | Cell Signaling, Growth Factors, TNF |
| PubChem ID | 44205240 |
| Scientific Background | Baricitinib acts as an inhibitor of janus kinase (JAK), blocking the subtypes JAK1 and JAK2, therby reducing cytokine release and suppressing the innate and adaptive immune systems. It was recently shown to significantly improve COVID-19 symptoms in a preliminary human trial, presumably through suppression of the cytokine release syndrome (“cytokine storm”) induced by SARS-CoV-2 infection. |
| References | 1."Summary of opinion for Olumiant" (PDF). European Medicines Agency (EMA). 15 December 2016. 2. Cantini F., et al. (2020) J. Infect. DOI: 10.1016/j.jinf.2020.04.017 |
Product Images
Chemical structure of Baricitinib (SIH-587), a Kinase inhibitor (pan-specific). CAS #: 1187594-09-7. Molecular Formula: C16H17N7O2S. Molecular Weight: 371.4 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.