Discovery through Partnership | Excellence through Quality
| Product Name | ML133 HCl |
| Description |
Potassium channel Blocker- Neuroprotective |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 1222781-70-5 |
| Molecular Formula | C19H19NO • HCl |
| Molecular Weight | 313.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Blocker |
| Solubility | May be dissolved in DMSO (32 mg/ml); or water (10 mg/ml, warm) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | COC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl |
| InChI | 1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H |
| InChIKey | NGQIBUUFXDPHKT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Danger. Hazard Statements: H302 - H315 - H318 - H335 - H400 Precautionary Statements: P273 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310 |
| Cite This Product | ML133 HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-617) |
Biological Description
| Alternative Names | N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine, hydrochloride |
| Research Areas | Ion Channels, Neuroscience, Neurotransmission, Neurotransmitter Receptors, Potassium Channels |
| PubChem ID | 44247466 |
| Scientific Background | ML133 HCl is a selective inhibitor of Kir2 inwardly rectifying potassium channels. In neuroscience, it has been shown to attenuate microglial proliferation and neuropathic pain behaviors following nerve injury. ML133 also inhibits microglial priming and improves neuronal survival in traumatic brain injury models, positioning Kir2.1 channels as novel therapeutic targets for neuroprotection and inflammation control in CNS disorders. |
| References |
1. Wang H.R. et al. 2011. ACS Chem. Biol. 6:845. 2. Gattlen C. et al. (2020) Glia 68:2119. 3. Spencer N.G. et al. (2016) PLoS One. 11(9):e0162497. 4. Lai J.D. et al. 2024. Cell Stem Cell 31:519. |
Product Images
Powered by Bioz
Reviews
There are no reviews yet.