Discovery through Partnership | Excellence through Quality
| Product Name | YM-58483 |
| Description |
CRAC channel blocker |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 223499-30-7 |
| Molecular Formula | C15H9F6N5OS |
| Molecular Weight | 421.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Blocker |
| Solubility | May be dissolved in DMSO (40 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F |
| InChI | 1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27) |
| InChIKey | XPRZIORDEVHURQ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | YM-58483 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-606) |
Biological Description
| Alternative Names | N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide; BTP2 |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Neurotransmission |
| PubChem ID | 2455 |
| Scientific Background | YM-58483 is a calcium release-activated calcium (CRAC) channel blocker that modulates mast cell responses and inhibits antigen-induced histamine release. It also exhibits potent T-cell antiproliferative activity. In neurodegenerative disease research, YM-58483 is explored for its ability to modulate immune cell activation and calcium signaling, which are implicated in neuroinflammation and neuroimmune interactions in disorders such as multiple sclerosis and Alzheimer’s disease. |
| References |
1.,Zitt. C., et al. (2004) J. Biol. Chem. 279(13): 12427-12437. 2.,Law M., et al. (2001) Int. J. Biochem. Cell Biol. 43:1228-1239. 3.,K Ohga et al. (2008) Int. Immunopharmacol. 8:1787-1792. |
Product Images
Chemical structure of YM-58483 (SIH-606), a CRAC channel blocker. CAS #: 223499-30-7. Molecular Formula: C15H9F6N5OS . Molecular Weight: 421.3 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.