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| Product Name | BML 277 |
| Description |
CHK2 kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 516480-79-8 |
| Molecular Formula | C20H14ClN3O2 |
| Molecular Weight | 363.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | C1=CC(=CC=C1C2=NC3=C(N2)C=CC(=C3)C(=O)N)OC4=CC=C(C=C4)Cl |
| InChI | InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24) |
| InChIKey | UXGJAOIJSROTTN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Bml 277 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-436) |
Biological Description
| Alternative Names | Chk2 Inhibitor II, Chk2 Inhibitor II hydrate, 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 9969021 |
| Scientific Background | Bml 277 is a highly selective inhibitor of Chk2, making it a useful tool for dissecting the role of Chk2 in cellular signaling. |
| References | 1. Pereg Y., et al. (2006) Mol. Cell Biol. 26(18): 6819–6831. |
Product Images
Chemical structure of BML 277 (SIH-436), a CHK2 kinase inhibitor. CAS #: 516480-79-8. Molecular Formula: C20H14ClN3O2. Molecular Weight: 363.8 g/mol.
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