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| Product Name | BRD 7389 |
| Description |
p90 RSK kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 376382-11-5 |
| Molecular Formula | C24H18N2O2 |
| Molecular Weight | 366.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | Orange powder |
| SMILES | C1=CC=C(C=C1)CCNC2=C3C4=CC=CC=C4C(=O)C5=C3C(=CC=C5)NC2=O |
| InChI | InChI=1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,20,25H,13-14H2 |
| InChIKey | QVEVXIXBUORVGE-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | BRD 7389 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-497) |
Biological Description
| Alternative Names | BRD7389, BRD-7389, 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione, 1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 24870634 |
| Scientific Background | BRD 7389 is a p90 ribosomal S6 kinase (RSK) inhibitor. Specifically, BRD7398 inhibits RSK1, RSK2 and RSK3. This compound has been seen to unregulate insulin expression in terminally differentiated pancreatic &alpha-cells. |
| References | 1. Fomina-Yadlin D., et al. (2010) Pro. Nat. Acad.Sci. USA. 107(34): 15099–15104. |
Product Images
Chemical structure of BRD 7389 (SIH-497), a p90 RSK kinase inhibitor. CAS #: 376382-11-5. Molecular Formula: C24H18N2O2. Molecular Weight: 366.4 g/mol.
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