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| Product Name | C8 Ceramide |
| Description |
Protein kinase activator |
| Purity | >98% (TLC) |
| CAS No. | 74713-59-0 |
| Molecular Formula | C26H51NO3 |
| Molecular Weight | 425.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml) |
| Source | Synthetic |
| Appearance | White waxy solid |
| SMILES | CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)NC(=O)CCCCCCC)O |
| InChI | InChI=1S/C26H51NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h19,21,24-25,28-29H,3-18,20,22-23H2,1-2H3,(H,27,30)/b21-19+/t24-,25+/m0/s1 |
| InChIKey | APDLCSPGWPLYEQ-WRBRXSDHSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | C8 Ceramide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-499) |
Biological Description
| Alternative Names | C8-Ceramide |
| Research Areas | Cell Signaling |
| PubChem ID | 5702614 |
| Scientific Background | C8 Ceramide is a cell-permeable analog of natural ceramides and functions as a bioactive lipid mediator. It activates protein kinases and induces apoptosis, making it a valuable tool in cell signaling studies. In neuroscience, C8 Ceramide is used to explore mechanisms of programmed cell death and neuroinflammation, both of which are central to neurodegenerative diseases. Its ability to modulate EGF receptor phosphorylation and downstream signaling pathways provides insights into neuronal survival and stress responses. |
| References |
1. Józefowski S., et al. (2010) J. Immun. (Baltimore, Md.: 1950). 185(11): 6960–6973. 2. Gusain A., et al. (2012) Mol.Neurobio. 45(3): 455–464. |
Product Images
Chemical structure of C8 Ceramide (SIH-499), a Protein kinase activator. CAS #: 74713-59-0. Molecular Formula: C26H51NO3. Molecular Weight: 425.7 g/mol.
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