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| Product Name | CAPE |
| Description |
NFkB Inhibitor |
| Purity | >98% |
| CAS No. | 104594-70-9 |
| Molecular Formula | C17H16O4 |
| Molecular Weight | 284.31 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO, acetone, ethanol, methanol, acetonitrile |
| Source | Synthetic |
| Appearance | Off-White Solid |
| SMILES | C1=CC=C(C=C1)CCOC(=O)/C=C/C2=CC(=C(C=C2)O)O |
| InChI | InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+ |
| InChIKey | SWUARLUWKZWEBQ-VQHVLOKHSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338 |
| Cite This Product | CAPE (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-263) |
Biological Description
| Alternative Names | 2-Phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate, Caffeic acid phenethyl ester |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5281787 |
| Scientific Background | CAPE , an active component of propolis from honeybee hives is known to have antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral properties (1). It specifically inhibits NF-κB activation and inhibits the growth of transformed cells (1). Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. |
| References | 1. Natarajan K., Singh S., Burke T.R., Grunberger D., Aggarwal B.B. (1996) Proc Natl Acad Sci USA. 93(17): 9090-9095. |
Product Images
Chemical structure of CAPE (SIH-263), a Inhibits NFkB activation. CAS #: 104594-70-9. Molecular Formula: C17H16O4. Molecular Weight: 284.31 g/mol.
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Based on validation through cited publications.