Capsaicin

Name: Capsaicin
SKU: SIH-322
Availability: InStock

TRPV1opener

Catalog No. SIH-322

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CAS No.	404-86-4
Molecular Formula	C18H27NO3

SKU: SIH-322 Categories: Inhibitor, Small Molecules

Product Name	Capsaicin
Description	TRPV1opener
Purity	>60% (HPLC); NMR (conforms)
CAS No.	404-86-4
Molecular Formula	C₁₈H₂₇NO₃
Molecular Weight	305.41
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Small Molecules
Solubility	Soluble in DMSO (20 mg/mL) and ethanol (15 mg/mL)
Source	Synthetic
Appearance	Off-White Solid
SMILES	CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChI	InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19
InChIKey	YKPUWZUDDOIDPM-SOFGYWHQSA-N
Safety Phrases	Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with shin and eyes Risk Phrases: R25-37/38-41-42/43 Hazard Phrases: H301-H311-H315-H317-H318-H334-H335 Precautionary Phrases: P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311
Cite This Product	Capsaicin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-322)

Alternative Names	(6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide
Research Areas	Ion Channels, Neuroscience, Transient Receptor Potential (TRP) Channels
PubChem ID	1548943
Scientific Background	Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel (1, 2). It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons (1). Powerful excitant of peripheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets (3).
References	1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824. 2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333. 3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.

Chemical structure of Capsaicin (SIH-322), a TRPV1opener. CAS #: 404-86-4. Molecular Formula: C18H27NO3. Molecular Weight: 305.41 g/mol.

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