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| Product Name | Carfilzomib |
| Description |
20S Proteasome inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 868540-17-4 |
| Molecular Formula | C40H57N5O7 |
| Molecular Weight | 719.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (80 mg/ml), or ethanol (25 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | O=C([C@]1(C)OC1)[C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCC2=CC=CC=C2)NC(CN3CCOCC3)=O)=O)CC(C)C)=O)CC4=CC=CC=C4)=O |
| InChI | 1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H |
| InChIKey | BLMPQMFVWMYDKT-NZTKNTHTSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled. Hazard statements: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Cite This Product | Carfilzomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-544) |
Biological Description
| Alternative Names | (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide, PR-17, Carfilzomib, Kyprolis, Carfilzomib (PR-171), PR-171, UNII-72X6E3J5AR |
| Research Areas | Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors |
| PubChem ID | 11556711 |
| Scientific Background | Carfilzomib / PR-17 is an irreversible proteasome inhibitor that targets the chymotrypsin-like beta5 subunit of 20S proteasome. It can arrest the cell cycle and trigger apoptosis in tumor cell lines. |
Product Images
Chemical structure of Carfilzomib (SIH-544), a 20S Proteasome inhibitor. CAS #: 868540-17-4. Molecular Formula: C40H57N5O7. Molecular Weight: 719.9 g/mol.
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