Celastrol

Name: Celastrol
SKU: SIH-333
Availability: InStock

Proteasome inhibitor

Catalog No. SIH-333

0 out of 5 based on 0 customer ratings

Reviews (0) | Datasheet

CAS No.	34157-83-0
Molecular Formula	C29H38O4

SKU: SIH-333 Categories: Inhibitor, Small Molecules

Product Name	Celastrol
Description	Proteasome inhibitor
Purity	>98%
CAS No.	34157-83-0
Molecular Formula	C₂₉H₃₈O₄
Molecular Weight	450.6
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol
Source	Synthetic
Appearance	Red Powder
SMILES	CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O
InChI	InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
InChIKey	KQJSQWZMSAGSHN-JJWQIEBTSA-N
Safety Phrases	Classification: Toxic- Toxic Material Causing Immediate and Serious Toxic Effects Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H301 – Toxic if swallowed Precautionary Statements: P301 + P31 – If Swallowed, immediately call a POISON CENTER or doctor.
Cite This Product	Celastrol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-333)

Alternative Names	3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors
PubChem ID	122724
Scientific Background	Displays potent antioxidant and anti-inflammatory activity. Inhibits NFB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. It inhibits 20S proteasome chymotrypsin activity (IC50=2.5 M). Cell permeable.
References	1. Sethi G., et al. (2007) Blood109: 2727. 2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053. 3. Yang H., et al. (2006) Cancer Res. 66: 4758.

Chemical structure of Celastrol (SIH-333), a Proteasome inhibitor. CAS #: 34157-83-0. Molecular Formula: C29H38O4. Molecular Weight: 450.6 g/mol.

There are no reviews yet.

Be the first to review “Celastrol”