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| Product Name | Clozapine |
| Description |
Dopamine receptor antagonist |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 5786-21-0 |
| Molecular Formula | C18H19ClN4 |
| Molecular Weight | 326.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | Soluble in DMSO (30 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow powder |
| SMILES | CN1CCN(CC1)C2=C3C=CC=CC3=Nc4ccc(Cl)cc4N2 |
| InChI | 1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 |
| InChIKey | ZUXABONWMNSFBN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion D2A Very Toxic Material Causing Other Toxic Effects - Teratogen D2B Toxic Material Causing Other Toxic Effects - Carcinogen, Moderate eye irritant, Mutagen Hazard statement(s): H301 Toxic if swallowed. H341 Suspected of causing genetic defects. H351 Suspected of causing cancer. H361 Suspected of damaging fertility or the unborn child. Precautionary statement(s): P281 Use personal protective equipment as required. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. |
| Cite This Product | Clozapine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-541-250MG) |
Biological Description
| Alternative Names | 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[c][1,5]benzodiazepine, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine, Clozapine, Leponex, Clozapin, CLOZARIL, Fazaclo |
| Research Areas | Neuroscience, Neurotransmitter Receptors |
| PubChem ID | 2818 |
| Scientific Background | Clozapine is an atypical antipsychotic widely recognized for its efficacy in treatment-resistant schizophrenia. It acts as a multi-receptor antagonist, particularly targeting serotonin (5-HT2A/2C) and dopamine receptors, which are critical in modulating mood, cognition, and perception. In neuroscience, Clozapine is frequently cited for its unique pharmacological profile that contributes to reduced extrapyramidal side effects and improved cognitive outcomes. Its influence on glutamatergic and cholinergic systems has also made it a subject of interest in neurodegenerative disease research, including Parkinson’s and Alzheimer’s disease. Clozapine’s neuroprotective and anti-inflammatory properties further enhance its relevance in studying the pathophysiology of neuropsychiatric and neurodegenerative disorders. |
Product Images
Chemical structure of Clozapine (SIH-541), a Dopamine receptor antagonist. CAS #: 5786-21-0. Molecular Formula: C18H19ClN4. Molecular Weight: 326.8 g/mol.
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