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| Product Name | Dibutyryl-cAMP |
| Description |
Activates PKA |
| Purity | ≥97% (HPLC); NMR (Conforms) |
| CAS No. | 16980-89-5 |
| Molecular Formula | C18H23N5O8P • Na |
| Molecular Weight | 491.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | May be dissolved in DMSO (50 mg/ml); water (50 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white powder |
| SMILES | CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+] |
| InChI | InChI=1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15 |
| InChIKey | KRBZRVBLIUDQNG-JBVYASIDSA-M |
| Safety Phrases | No hazard pictogram, no signal word, no hazard statement(s), no precautionary statement(s) required |
| Cite This Product | Dibutyryl-cAMP (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-632) |
Biological Description
| Alternative Names | N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt; Bucladesine Na |
| Research Areas | Cell Signaling, Neuroscience, Neurotransmission, Protein Phosphorylation, Serine / Threonine Kinases, Stem Cells, Neural Stem Cells, PKA |
| PubChem ID | 23663967 |
| Scientific Background | Dibutyryl-cAMP is a cell-permeable analog of cyclic AMP that mimics endogenous cAMP signaling. It activates protein kinase A (PKA) and promotes morphological differentiation of astrocytes and dopaminergic neurons. In stem cell research, it is used to induce neuronal differentiation and maturation. Dibutyryl-cAMP is a valuable tool in neuroscience for studying cAMP-mediated signaling pathways and their roles in neurodevelopment and neurodegenerative disease models. |
| References |
1.,M Bartsch et al. Biol. Chem. 2003 384:1321 2.,ML Carranza et al. J. Physiol. 1998 15:511 3.,YJ Hei et al. Mol. Pharmacol. 1991 39:233 4.,M Imamura et al. Proc. Natl. Acad. Sci. USA 1998 95:6139 5.,N Xia et al. Sci. Rep. 2016 6:20270 |
Product Images
Chemical structure of Dibutyryl-cAMP (SIH-632), a Activates PKA. CAS #: 16980-89-5. Molecular Formula: C18H23N5O8P • Na. Molecular Weight: 491.4 g/mol.
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