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| Product Name | Dofetilide |
| Description |
Herg channel blocker |
| Purity | >98% |
| CAS No. | 115256-11-6 |
| Molecular Formula | C19H27N3O5S2 |
| Molecular Weight | 441.56 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C |
| InChI | InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H |
| InChIKey | IXTMWRCNAAVVAI-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S53 - Avoid exposure - obtain special instruction before use S57 - Use appropriate containment to avoid environmental contamination Risk Phrases: R22 - Harmful if swallowed R48 - Danger of serious damage to health by prolonged exposure R51/53 - Toxic to aquatic organisms, may cause longterm adverse effects in the aquatic environment R61 - May cause harm to the unborn child R62 - Possible risk of impaired fertility Hazard Phrases: H302-H319-H360 Precautionary Phrases: P201-P305 + P351 + P338-P308 + P313 |
| Cite This Product | Dofetilide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-311) |
Biological Description
| Alternative Names | N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide, Tikosyn, UK 68798 |
| Research Areas | Ion Channels, Neuroscience |
| PubChem ID | 71329 |
| Scientific Background | Dofetilide is a class III antiarrhythnic agent (1). It works by selectively blocking the rapid component of the delayed rectifier outward potassium current (2). |
| References |
1. Lentz T.L., Hilleman D.E. (2000) Pharmacotherapy. 20(7): 776-786. 2. Roukoz H., Saliba W. (2007) Expert Rev Cardiovasc Ther. 5(1): 9-19. |
Product Images
Chemical structure of Dofetilide (SIH-311), a Herg channel blocker. CAS #: 115256-11-6. Molecular Formula: C19H27N3O5S2. Molecular Weight: 441.56 g/mol.
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