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| Product Name | Doramapimod |
| Description |
p38 MAP kinase inhibitor |
| Purity | >99% (HPLC) |
| CAS No. | 285983-48-4 |
| Molecular Formula | C31H37N5O3 |
| Molecular Weight | 527.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | C2=CC(=C1C=CC=CC1=C2NC(NC3=CC(=N[N]3C4=CC=C(C=C4)C)C(C)(C)C)=O)OCCN5CCOCC5 |
| InChI | InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) |
| InChIKey | MVCOAUNKQVWQHZ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Doramapimod (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-442) |
Biological Description
| Alternative Names | JNK Inhibitor XVII, BIRB796, 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 156422 |
| Scientific Background | Doramapimod is a highly potent and selective inhibitor of p38α MAPK. It specifically blocks TNFα release. |
| References | 1. Pargellis C., et al. (2002). Nat Structural Biol. 9(4): 268–272. |
Product Images
Chemical structure of Doramapimod (SIH-442), a p38 MAP kinase inhibitor. CAS #: 285983-48-4. Molecular Formula: C31H37N5O3. Molecular Weight: 527.7 g/mol.
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