Duloxetine Hydrochloride

5-HT-noradrenaline reuptake inhibitor

Catalog No. SIH-549

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CAS No. 136434-34-9
Molecular Formula C18H19NOS.HCl
SKU: SIH-549 Categories: ,

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SIH-549-Duloxetine-HCl-Chemical-Structure.png
Product Name Duloxetine Hydrochloride
Description

5-HT-noradrenaline reuptake inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 136434-34-9
Molecular Formula C18H19NOS.HCl
Molecular Weight 333.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Product Type Inhibitor
Solubility May be dissolved in DMSO (30 mg/ml); or water (3 mg/ml)
Source Synthetic
Appearance White powder
SMILES CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl
InChI InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
InChIKey BFFSMCNJSOPUAY-LMOVPXPDSA-N
Safety Phrases WHMIS Classification:
Not WHMIS controlled.

GHS Classification:
Acute toxicity, Oral (Category 4)

Signal word: Warning

Hazard statement(s):
H302 Harmful if swallowed.
Precautionary statement(s) none

HMIS Classification:
Health hazard: 1
Flammability: 0
Physical hazards: 0

Potential Health Effects:
Inhalation - May be harmful if inhaled. May cause respiratory tract irritation.
Skin - Harmful if absorbed through skin. May cause skin irritation.
Eyes - May cause eye irritation.
Ingestion - Harmful if swallowed.
Cite This Product Duloxetine HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-549)

Biological Description

Alternative Names Duloxetine Hydrochloride, (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride, (S)-Duloxetine hydrochloride, (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride, (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride, (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine;hydrochloride, Duloxetine HCl
Research Areas Alpha-2 Adrenergic Receptors, Neuroscience, Neurotransmitter Receptors
PubChem ID 60834
Scientific Background Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) widely used in the treatment of depression and neuropathic pain. In neurodegenerative disease research, Duloxetine has been investigated for its ability to modulate neuroinflammation, enhance neuroplasticity, and protect against neuronal loss. Its dual-action mechanism on monoaminergic pathways supports its use in managing cognitive and emotional symptoms associated with neurodegenerative disorders.

Product Images

<p>Chemical structure of Duloxetine HCl (SIH-549), a 5-HT-noradrenaline reuptake inhibitor. CAS #: 136434-34-9. Molecular Formula: C18H19NOS.HCl. Molecular Weight: 333.9 g/mol.</p>

Chemical structure of Duloxetine HCl (SIH-549), a 5-HT-noradrenaline reuptake inhibitor. CAS #: 136434-34-9. Molecular Formula: C18H19NOS.HCl. Molecular Weight: 333.9 g/mol.

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