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| Product Name | Flupirtine maleate |
| Description |
Kv7 channel activator |
| Purity | >98% (HPLC) |
| CAS No. | 75507-68-5 |
| Molecular Formula | C15H17FN4O2•C4H4O4 |
| Molecular Weight | 420.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | Soluble in DMSO (100 mM) and ethanol (10 mM) |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CCOC(=O)NC1=C(N=C(C=C1)NCC2=CC=C(C=C2)F)N.C(=CC(=O)O)C(=O)O |
| InChI | InChI=1S/C15H17FN4O2.C4H4O4/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10;5-3(6)1-2-4(7)8/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | DPYIXBFZUMCMJM-BTJKTKAUSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Flupirtine maleate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-376) |
Biological Description
| Alternative Names | N-[2-Amino-6-[[4-fluorophenyl)methy-l]amino]-3-pyridinyl]carbamic acid ethyl ester maleate |
| Research Areas | Ion Channels, Neuroscience, Potassium Channels, Voltage-Gated Potassium Channels |
| PubChem ID | 6435335 |
| Scientific Background | Flupirtine maleate is a non-opioid analgesic with neuroprotective properties, acting as a selective neuronal potassium channel opener and NMDA receptor antagonist. In neurodegenerative disease research, flupirtine has been shown to reduce excitotoxicity, oxidative stress, and apoptosis in neuronal cells. It enhances mitochondrial function and supports neuronal survival, making it a candidate for therapeutic intervention in conditions such as Alzheimer’s and Parkinson’s disease. Its dual action on pain modulation and neuroprotection underscores its relevance in neuroscience. |
| References |
1. Naser SM., Sarkar N., Biswas A., Kamal F., Prakash R., Rahaman QM., Das AK. (2012) J Indian med Assoc. 110(3): 158-60. 2. Harish S., Bhuvana K., Bengalorkar G. and Kumar TN. (2012) J Anaethesiol Clin Pharmacol. 28(2): 172-177. |
Product Images
Chemical structure of Flupirtine maleate (SIH-376), a Kv7 channel activator. CAS #: 75507-68-5. Molecular Formula: C15H17FN4O2.C4H4O4. Molecular Weight: 420.4 g/mol.
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