17-AAG

Hsp90 inhibitor

Catalog No. SIH-100

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CAS No. 75747-14-7
Molecular Formula C31H43N3O8
SKU: SIH-100 Categories: ,

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SIH-100_17-AAG_Chemical_Structure.png
Product Name 17-AAG
Description

Hsp90 inhibitor

Purity >99% (HPLC); NMR (Conforms)
CAS No. 75747-14-7
Molecular Formula C31H43N3O8
Molecular Weight 585.7
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (>50 mg/ml) or ethanol (5 mg/ml)
Source Synthetic
Appearance Red to dark red powder
SMILES C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)C)C)O)OC
InChI InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30
InChIKey AYUNIORJHRXIBJ-TXHRRWQRSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product 17-AAG (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-100)

Biological Description

Alternative Names 17-(Allylamino)-17-demethoxygeldanamycin, 17-(Allylamino)geldanamycin, 17-Demethoxy-17-allylamino geldanamycin, 17-AAG, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507, Tanespimycin
Research Areas Cancer, Heat Shock
PubChem ID 6505803
Scientific Background 17-AAG (17-allylamino-17-demethoxygeldanamycin) is a potent inhibitor of heat shock protein 90 (HSP90), a molecular chaperone essential for the stability and function of numerous client proteins involved in cell signaling, survival, and protein homeostasis. Originally developed as an anticancer agent due to its selective affinity for tumor-derived HSP90, 17-AAG has gained attention in neuroscience for its ability to modulate protein degradation pathways. Notably, 17-AAG induces autophagy, a cellular clearance mechanism critical for the removal of misfolded proteins such as alpha-synuclein—an aggregation-prone protein implicated in Parkinson’s disease and other synucleinopathies. By promoting autophagic flux, 17-AAG may help restore proteostasis in neural cells and reduce neurotoxicity associated with protein aggregation. Its dual role in inhibiting Akt signaling and enhancing protein clearance positions 17-AAG as a promising candidate for therapeutic exploration in neurodegenerative disorders characterized by proteotoxic stress.
References 1. Neckers L. (2002) Trends Mol Med. 84: S55-61.
2. Kamal A., et al.(2003) Nature. 425: 407.
3. Solit D.B., et al.(2003) Cancer Res. 63: 2139.
4. Vasilevskaya I.A., et al. (2003) Mol.Pharmacol. 65: 235.
5. Jia W., et al.(2003) Blood. 102: 1824.
6. Riedel M., Goldbaum O., Schwarz L., Schmitt S., Richter-Landsberg C. (2010) PLOS ONE. 5(1): e8753. https://doi.org/10.1371/journal.pone.0008753

Product Images

<p>Chemical structure of 17-AAG (SIH-100), a Hsp90 inhibitor. CAS #: 75747-14-7. Molecular Formula: C31H43N3O8. Molecular Weight: 585.7 g/mol.</p>

Chemical structure of 17-AAG (SIH-100), a Hsp90 inhibitor. CAS #: 75747-14-7. Molecular Formula: C31H43N3O8. Molecular Weight: 585.7 g/mol.

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