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| Product Name | AAL-993 |
| Description |
VEGFR inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 269390-77-4 |
| Molecular Formula | C20H16F3N3O |
| Molecular Weight | 371.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (>25 mg/ml) or ethanol (15 mg/ml) |
| Source | Synthetic |
| Appearance | Pale yellow solid |
| SMILES | C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3 |
| InChI | InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27) |
| InChIKey | BLAFVGLBBOPRLP-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | AAL 993 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-424) |
Biological Description
| Alternative Names | 2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Growth Factor Receptor Inhibitors |
| PubChem ID | 6398883 |
| Scientific Background | AAL-993 is a very potent inhibitor of VEGFR-1, VEGFR-2 and VEGFR-3, as well as PDGFR-β, c-Kit and CSF-1R at higher concentrations. |
| References |
1. Manley P.W., et al. (2004) Biochimica Biophysica Acta. 1697(1-2): 17–27. 2. Ban H.S., Uno M., & Nakamura H. (2010) Cancer Letters. 296(1): 17–26. |
Product Images
Chemical structure of AAL 993 (SIH-424), a VEGFR inhibitor. CAS #: N/A. Molecular Formula: C20H16F3N3O. Molecular Weight: 371.4 g/mol.
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