AG 494

EGFR kinase inhibitor

Catalog No. SIH-491

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CAS No. 133550-35-3
Molecular Formula C16H12N2O3
SKU: SIH-491 Categories: ,

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SIH-491_AG-494_Chemical_Structure.png
Product Name AG 494
Description

EGFR kinase inhibitor

Purity >98% (TLC)
CAS No. 133550-35-3
Molecular Formula C16H12N2O3
Molecular Weight 280.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)
Source Synthetic
Appearance Yellow solid
SMILES C1=CC=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
InChI InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
InChIKey HKHOVJYOELRGMV-XYOKQWHBSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product AG 494 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-491)

Biological Description

Alternative Names AG-494, (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 5328771
Scientific Background AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically blocks EGFR autophosphorylation and EGF-dependent cell proliferation. In neuroscience, AG 494 is used to investigate the role of EGFR signaling in neural development, gliogenesis, and neuroinflammation. Its ability to modulate growth factor signaling makes it a valuable tool for studying glioblastoma and other EGFR-related neuropathologies.
References 1. Ben-Bassat H., et al. (1999).J. Pharm. Exp. Ther. 290(3): 1442–1457.
2. Kleinberger-Doron N., Shelah N., Capone R., Gazit A., & Levitzki A. (1998) Exp. Cell . Res. 241(2): 340–351.

Product Images

<p>Chemical structure of AG 494 (SIH-491), a EGF receptor tyrosine kinase inhibitor. CAS #: 133550-35-3. Molecular Formula: C16H12N2O3. Molecular Weight: 280.3 g/mol.</p>

Chemical structure of AG 494 (SIH-491), a EGF receptor tyrosine kinase inhibitor. CAS #: 133550-35-3. Molecular Formula: C16H12N2O3. Molecular Weight: 280.3 g/mol.

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