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| Product Name | AG 494 |
| Description |
EGFR kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 133550-35-3 |
| Molecular Formula | C16H12N2O3 |
| Molecular Weight | 280.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | C1=CC=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N |
| InChI | InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+ |
| InChIKey | HKHOVJYOELRGMV-XYOKQWHBSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | AG 494 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-491) |
Biological Description
| Alternative Names | AG-494, (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5328771 |
| Scientific Background | AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically blocks EGFR autophosphorylation and EGF-dependent cell proliferation. In neuroscience, AG 494 is used to investigate the role of EGFR signaling in neural development, gliogenesis, and neuroinflammation. Its ability to modulate growth factor signaling makes it a valuable tool for studying glioblastoma and other EGFR-related neuropathologies. |
| References |
1. Ben-Bassat H., et al. (1999).J. Pharm. Exp. Ther. 290(3): 1442–1457. 2. Kleinberger-Doron N., Shelah N., Capone R., Gazit A., & Levitzki A. (1998) Exp. Cell . Res. 241(2): 340–351. |
Product Images
Chemical structure of AG 494 (SIH-491), a EGF receptor tyrosine kinase inhibitor. CAS #: 133550-35-3. Molecular Formula: C16H12N2O3. Molecular Weight: 280.3 g/mol.
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