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| Product Name | AG 879 |
| Description |
NGFR kinase inhibitor |
| Purity | 99% (TLC) |
| CAS No. | 148741-30-4 |
| Molecular Formula | C18H24N2OS |
| Molecular Weight | 316.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC(C1=CC(C=C(C(C)(C)C)C1=O)=CC(=C(S)N)C#N)(C)C |
| InChI | InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+ |
| InChIKey | LCUMYVYIHXYBIA-FOWTUZBSSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | AG 879 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-429) |
Biological Description
| Alternative Names | Tyrphostin AG 879, α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5487525 |
| Scientific Background |
AG 879 is a selective inhibitor of the tyrosine kinase activity of the nerve growth factor (NGF) receptor TrkA, with additional inhibitory effects on ErbB2 and VEGFR-2. In neuroscience, AG 879 is primarily used to investigate NGF-TrkA signaling, a pathway critical for neuronal survival, differentiation, and axonal growth. Dysregulation of NGF signaling has been implicated in neurodegenerative diseases such as Alzheimer’s and peripheral neuropathies, where impaired neurotrophic support contributes to neuronal loss and synaptic dysfunction. By inhibiting TrkA, AG 879 enables researchers to dissect the role of NGF in maintaining neuronal integrity and to model conditions of neurotrophin deprivation. Its additional activity against ErbB2 and VEGFR-2 expands its utility in studying neurovascular interactions and glial responses, particularly in the context of neuroinflammation and blood-brain barrier regulation. AG 879 is a valuable tool for exploring therapeutic strategies aimed at modulating neurotrophic signaling and protecting against neurodegeneration. |
| References |
1. He H., et al. (2004) Cancer Biol. Therapy. 3(1): 96–101. 2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658. |
Product Images
Chemical structure of AG 879 (SIH-429), a NGFR kinase inhibitor. CAS #: 148741-30-4. Molecular Formula: C18H24N2OS. Molecular Weight: 316.5 g/mol.
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