AG 879

NGFR kinase inhibitor

Catalog No. SIH-429

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CAS No. 148741-30-4
Molecular Formula C18H24N2OS
SKU: SIH-429 Categories: ,

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SIH-429_AG-879_Chemical_Structure.png
Product Name AG 879
Description

NGFR kinase inhibitor

Purity 99% (TLC)
CAS No. 148741-30-4
Molecular Formula C18H24N2OS
Molecular Weight 316.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml)
Source Synthetic
Appearance Yellow solid
SMILES CC(C1=CC(C=C(C(C)(C)C)C1=O)=CC(=C(S)N)C#N)(C)C
InChI InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+
InChIKey LCUMYVYIHXYBIA-FOWTUZBSSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product AG 879 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-429)

Biological Description

Alternative Names Tyrphostin AG 879, α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 5487525
Scientific Background AG 879 is a selective inhibitor of the tyrosine kinase activity of the nerve growth factor (NGF) receptor TrkA, with additional inhibitory effects on ErbB2 and VEGFR-2. In neuroscience, AG 879 is primarily used to investigate NGF-TrkA signaling, a pathway critical for neuronal survival, differentiation, and axonal growth. Dysregulation of NGF signaling has been implicated in neurodegenerative diseases such as Alzheimer’s and peripheral neuropathies, where impaired neurotrophic support contributes to neuronal loss and synaptic dysfunction.

By inhibiting TrkA, AG 879 enables researchers to dissect the role of NGF in maintaining neuronal integrity and to model conditions of neurotrophin deprivation. Its additional activity against ErbB2 and VEGFR-2 expands its utility in studying neurovascular interactions and glial responses, particularly in the context of neuroinflammation and blood-brain barrier regulation. AG 879 is a valuable tool for exploring therapeutic strategies aimed at modulating neurotrophic signaling and protecting against neurodegeneration.
References 1. He H., et al. (2004) Cancer Biol. Therapy. 3(1): 96–101.
2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658.

Product Images

<p>Chemical structure of AG 879 (SIH-429), a NGFR kinase inhibitor. CAS #: 148741-30-4. Molecular Formula: C18H24N2OS. Molecular Weight: 316.5 g/mol.</p>

Chemical structure of AG 879 (SIH-429), a NGFR kinase inhibitor. CAS #: 148741-30-4. Molecular Formula: C18H24N2OS. Molecular Weight: 316.5 g/mol.

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