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| Product Name | Apigenin |
| Description |
Protein kinase inhibitor |
| Purity | >98% |
| CAS No. | 520-36-5 |
| Molecular Formula | C15H10O5 |
| Molecular Weight | 270.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 50 mM in DMSO |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O |
| InChI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H |
| InChIKey | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68 - Possible risk of irreversible effects |
| Cite This Product | Apigenin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-249) |
Biological Description
| Alternative Names | 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors |
| PubChem ID | 5280443 |
| Scientific Background | Apigenin is a naturally occurring flavonoid with neuroprotective and anti-inflammatory properties. It induces autophagy, a cellular degradation pathway essential for clearing damaged proteins and organelles, which is particularly relevant in neurodegenerative diseases. Apigenin also modulates cytochrome P450 enzymes, notably inhibiting CYP2C9, and has been shown to counteract the neurotoxic effects of immunosuppressants like cyclosporine. Its antioxidant activity and ability to cross the blood-brain barrier make it a promising candidate for therapeutic development in conditions such as Alzheimer's disease and Parkinson's disease. |
| References |
1. Ruela-de-Sousa R.R., et al. (2010) Cell Death and Disease. 1(e19): 1-11. 2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634. 3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327. |
Product Images
Chemical structure of Apigenin (SIH-249), a Protein kinase inhibitor. CAS #: 520-36-5. Molecular Formula: C15H10O5. Molecular Weight: 270.2 g/mol.
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