AS 041164

PI 3-Kgamma kinase inhibitor

Catalog No. SIH-433

0 out of 5 based on 0 customer ratings
CAS No. 6318-41-8
Molecular Formula C11H7NO4S
SKU: SIH-433 Categories: ,

Clear
SIH-433_AS-041164_Chemical_Structure.png
Product Name AS 041164
Description

PI 3-Kgamma kinase inhibitor

Purity >98% (TLC)
CAS No. 6318-41-8
Molecular Formula C11H7NO4S
Molecular Weight 249.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (25 mg/ml). For in vivo administration this compound was suspended in 0.5% carboxymethylcellulose/0.25% Tween 20 as a vehicle
Source Synthetic
Appearance Yellow solid
SMILES C2=C(C=C1/C(NC(S1)=O)=O)C=CC3=C2OCO3
InChI InChI=1S/C11H7NO4S/c13-10-9(17-11(14)12-10)4-6-1-2-7-8(3-6)16-5-15-7/h1-4H,5H2,(H,12,13,14)
InChIKey SDGWAUUPHUBJNQ-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product AS 041164 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-433)

Biological Description

Alternative Names NSC31098, 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 233033
Scientific Background AS 041164 is a selective inhibitor of the PI3Kγ isoform, a key regulator of immune cell signaling and migration. In neuroscience, PI3Kγ has been implicated in neuroinflammatory responses and microglial activation, processes that contribute to the progression of neurodegenerative diseases. By blocking PI3Kγ activity, AS 041164 can modulate leukocyte trafficking and reduce neuroinflammation, making it a valuable tool for studying immune-mediated mechanisms in conditions such as multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease. Its ability to inhibit neutrophil migration further supports its application in models of neurovascular inflammation and blood-brain barrier dysfunction.
References 1. Ferrandi C., et al. (2007) J. Pharmacol. Exp.Ther. 322(3): 923–930.

Product Images

<p>Chemical structure of AS 041164  (SIH-433), a PI 3-Kgamma kinase inhibitor. CAS #: 6318-41-8. Molecular Formula: C11H7NO4S. Molecular Weight: 249.2 g/mol.</p>

Chemical structure of AS 041164 (SIH-433), a PI 3-Kgamma kinase inhibitor. CAS #: 6318-41-8. Molecular Formula: C11H7NO4S. Molecular Weight: 249.2 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “AS 041164”

Your email address will not be published. Required fields are marked *