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| Product Name | AS-8351 |
| Description |
KDM5B histone demethylase inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 796-42-9 |
| Molecular Formula | C17H13N3O2 |
| Molecular Weight | 291.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (45 mg/ml); or ethanol (10 mg/ml, warm); or DMF (30 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow powder |
| SMILES | O=C(NNC=C1/C(=O)C=Cc2ccccc12)c3ccncc3 |
| InChI | InChI=1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,19H,(H,20,22)/b15-11- |
| InChIKey | UBECDIQQXGETMR-PTNGSMBKSA-N |
| Safety Phrases |
GHS Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Signal word: Warning Hazard statement(s): H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s): P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | AS-8351 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-558) |
Biological Description
| Alternative Names | AS8351, 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone; NSC-51355, N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide, N'-[(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide, N'-[(Z)-(2-oxo-1-naphthylidene)methyl]pyridine-4-carbohydrazide, N'-[(2-oxo-1-naphthylidene)methyl]pyridine-4-carbohydrazide, N'-[(Z)-(2-oxo-1-naphthylidene)methyl]-4-pyridinecarbohydrazide, N'-[(2-oxo-1-naphthylidene)methyl]-4-pyridinecarbohydrazide, N'-[(Z)-(2-keto-1-naphthylidene)methyl]isonicotinohydrazide, N'-[(2-keto-1-naphthylidene)methyl]isonicotinohydrazide, 796-42-9, 2-Hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone, NSC51355, NCI60_004242, ZINC00061171, CBDivE_006818, 311 Iron Chelator, 2-Hydroxy-1-naphthaldehyde isonicotinoyl hydrazone |
| Research Areas | Stem Cells |
| PubChem ID | 5353827 |
| Scientific Background | AS-8351 is a selective inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic regulator involved in chromatin remodeling and gene expression. In neurodegenerative disease research, LSD1 inhibition is being explored for its potential to modulate neurogenesis, synaptic plasticity, and memory formation. AS-8351 is used to study the impact of histone demethylation on neuronal differentiation and survival, particularly in models of Alzheimer’s disease and cognitive decline. Its role in epigenetic regulation makes it a promising compound for investigating transcriptional dysregulation in the aging brain. |
Product Images
Chemical structure of AS-8351 (SIH-558), a KDM5B histone demethylase inhibitor. CAS #: 796-42-9. Molecular Formula: C17H13N3O2. Molecular Weight: 291.3 g/mol.
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