Astemizole

Herg channel blocker

Catalog No. SIH-302

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CAS No. 68844-77-9
Molecular Formula C28H31FN4O
SKU: SIH-302 Categories: ,

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SIH-302_Astemizole_Chemical_Structure.png
Product Name Astemizole
Description

Herg channel blocker

Purity >98%
CAS No. 68844-77-9
Molecular Formula C28H31FN4O
Molecular Weight 458.57
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO and to 25 mM in ethanol
Source Synthetic
Appearance White solid
SMILES COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
InChI InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-2
InChIKey GXDALQBWZGODGZ-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62 - Possible risk of impaired fertility
Hazard Phrases:
H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Cite This Product Astemizole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-302)

Biological Description

Alternative Names 1-(4-Fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine, Hismanal
Research Areas Ion Channels, Neuroscience
PubChem ID 2247
Scientific Background Astemizole is a second-generation antihistamine that binds to peripheral histamine H1 receptors in tissues such as the gastrointestinal tract, uterus, and bronchial muscle. Although it does not cross the blood-brain barrier, its peripheral selectivity makes it useful in studying histamine-related signaling and its indirect effects on the nervous system. It is metabolized by CYP3A4 and has been explored for its off-target effects in neuropharmacology.
References 1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300.
2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.

Product Images

<p>Chemical structure of Astemizole (SIH-302), a Herg channel blocker. CAS #: 68844-77-9. Molecular Formula: C28H31FN4O. Molecular Weight: 458.57 g/mol.</p>

Chemical structure of Astemizole (SIH-302), a Herg channel blocker. CAS #: 68844-77-9. Molecular Formula: C28H31FN4O. Molecular Weight: 458.57 g/mol.

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