Discovery through Partnership | Excellence through Quality
| Product Name | AZD6244 |
| Description |
ERK kinase inhibitor |
| Purity | >98% |
| CAS No. | 606143-52-6 |
| Molecular Formula | C17H15BrClFN4O3 |
| Molecular Weight | 457.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (92 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C) |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO |
| InChI | InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) |
| InChIKey | CYOHGALHFOKKQC-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Serious Eye Damage/Eye Irritation, Category 1 Skin Sensitization, Category 1 Toxic To Reproduction, Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H318: Causes serious eye damage. H317: May cause an allergic skin reaction. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage to {Liver, gastrointestinal tract and other major organs} through prolonged or repeated exposure. Precautionary statements: P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}. P272: Contaminated work clothing should not be allowed out of the workplace. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a {POISON CENTER/doctor/...}. P302+352: IF ON SKIN: Wash with plenty of soap and water. P333+313: If skin irritation or rash occurs, seek medical advice/attention. P308+313: IF exposed or concerned: Get medical attentiodvice. P314: Get medical attentiodvice if you feel unwell. |
| Cite This Product | AZD6244 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-495) |
Biological Description
| Alternative Names | Selumetinib, AZD6244, 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 10127622 |
| Scientific Background | AZD6244 (also known as Selumetinib) is a selective MEK1 inhibitor that blocks the phosphorylation of ERK1/2, key components of the MAPK/ERK signaling pathway. While it has been extensively studied in oncology for its ability to suppress tumor growth, its modulation of MAPK signaling has implications for neuroscience. Dysregulation of the MAPK/ERK pathway is associated with neuroinflammation, synaptic dysfunction, and neuronal death in various neurodegenerative diseases. AZD6244’s ability to modulate this pathway positions it as a potential therapeutic candidate for conditions such as Alzheimer’s disease and multiple sclerosis. Its pharmacological profile and ability to cross the blood-brain barrier make it a compound of interest for translational neuroscience research. |
| References | 1. Haasbach E., Hartmayer C., & Planz O. (2013) Antiviral Research. 98(2): 319–324. |
Product Images
Chemical structure of AZD6244 (SIH-495), a ERK kinase inhibitor. CAS #: 606143-52-6. Molecular Formula: C17H15BrClFN4O3. Molecular Weight: 457.7 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.