Discovery through Partnership | Excellence through Quality
| Product Name | BAY 11-7082 |
| Description |
IKK kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 19542-67-7 |
| Molecular Formula | C10H9NO2S |
| Molecular Weight | 207.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 25 mM in ethanol and to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | C1=C([S](=O)(=O)C=CC#N)C=CC(=C1)C |
| InChI | InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+ |
| InChIKey | DOEWDSDBFRHVAP-KRXBUXKQSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | BAY 11 7082 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-434) |
Biological Description
| Alternative Names | Bay 11-7821, (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5353431 |
| Scientific Background | BAY 11-7082 is an anti-inflammatory compound that inhibits cytokine-induced phosphorylation of IκBα, thereby suppressing NF-κB activation. It also functions as an inhibitor of E2 ubiquitin-conjugating enzymes and can induce apoptosis. In neurodegenerative disease research, BAY 11-7082 is used to study the role of NF-κB signaling in neuroinflammation, glial activation, and neuronal survival. Its ability to modulate inflammatory pathways makes it a valuable tool for investigating therapeutic strategies aimed at reducing chronic inflammation in diseases such as Alzheimer’s, ALS, and multiple sclerosis. |
| References |
1. Mori N., et al. (2002) Blood 100(5): 1828–1834. 2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103. |
Product Images
Chemical structure of BAY 11 7082 (SIH-434), a IKK kinase inhibitor. CAS #: 19542-67-7. Molecular Formula: C10H9NO2S. Molecular Weight: 207.3 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.