BIBW 2992

EGFR, HER2 kinase inhibitor

Catalog No. SIH-496

0 out of 5 based on 0 customer ratings
CAS No. 850140-72-6
Molecular Formula C24H25ClFN5O3
SKU: SIH-496 Categories: ,

Clear
SIH-496_BIBW_2992_Chemical_Structure.png
Product Name BIBW 2992
Description

EGFR, HER2 kinase inhibitor

Purity >99%
CAS No. 850140-72-6
Molecular Formula C24H25ClFN5O3
Molecular Weight 485.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml
Source Synthetic
Appearance Crystalline solid
SMILES CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
InChI InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChIKey ULXXDDBFHOBEHA-CWDCEQMOSA-N
Safety Phrases Classification:
Acute Toxicity: Oral, Category 2
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 1
Toxic To Reproduction, Category 2
Target Organ Systemic Toxicity (repeated exposure), Category 2

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H300: Fatal if swallowed.
H315: Causes skin irritation.
H318: Causes serious eye damage.
H361: Suspected of damaging fertility or the unborn child.
H373: May cause damage through prolonged or repeated exposure.

Precautionary statements:
P264: Wash {hands} thoroughly after handling.
P280: Wear {protective gloves/protective clothing/eye protection/face protection}.
P362+364: Take off contaminated clothing and wash it before reuse.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P260: Do not breathe {dust/fume/gas/mist/vapours/spray}.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330: Rinse mouth.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a {POISON CENTER/doctor/...}.
P308+313: IF exposed or concerned: Get medical attentiodvice.
P314: Get medical attentiodvice if you feel unwell.
Cite This Product BIBW 2992 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-496)

Biological Description

Alternative Names Afatinib, N-​[4-​[(3-​chloro-​4-​fluorophenyl)amino]-​7-​[[(3S)-​tetrahydro-​3-​furanyl]oxy]-​6-​quinazolinyl]-​4-​(dimethylamino)-​2-​butenamide
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 10184653
Scientific Background BIBW 2992 (Afatinib) is a potent and irreversible inhibitor of the ErbB family of receptors, including EGFR and HER2. Primarily developed for oncology applications, particularly in non-small cell lung cancer, its inhibition of EGFR signaling has broader implications. In the nervous system, EGFR signaling is involved in neurodevelopment, synaptic plasticity, and response to injury. Although BIBW 2992 is not widely used in neuroscience, its mechanism of action suggests potential utility in modulating neuroinflammatory responses and glial activation. Further research may uncover its relevance in neurodegenerative disease models where aberrant EGFR signaling contributes to pathology.
References 1. Ioannou, N., et al. (2011) Br. J. Cancer. 105(10): 1554–1562.

Product Images

<p>Chemical structure of BIBW 2992 (SIH-496), a EGFR and HER2 kinase inhibitor. CAS #: 439081-18-2. Molecular Formula: C24H25ClFN5O3. Molecular Weight: 485.9 g/mol.</p>

Chemical structure of BIBW 2992 (SIH-496), a EGFR and HER2 kinase inhibitor. CAS #: 439081-18-2. Molecular Formula: C24H25ClFN5O3. Molecular Weight: 485.9 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “BIBW 2992”

Your email address will not be published. Required fields are marked *