Bml 259

CDK5, p25 kinase inhibitor

Catalog No. SIH-435

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CAS No. 267654-00-2
Molecular Formula C14H16N2OS
SKU: SIH-435 Categories: ,

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SIH-435_BML-259_Chemical_Structure.png
Product Name Bml 259
Description

CDK5, p25 kinase inhibitor

Purity >98% (TLC)
CAS No. 267654-00-2
Molecular Formula C14H16N2OS
Molecular Weight 260.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (30 mg/ml), dimethyl formamide (30 mg/ml) or 100% ethanol (0.25 mg/ml)
Source Synthetic
Appearance White solid
SMILES CC(C)C1=CN=C(S1)NC(=O)CC2=CC=CC=C2
InChI InChI=1S/C14H16N2OS/c1-10(2)12-9-15-14(18-12)16-13(17)8-11-6-4-3-5-7-11/h3-7,9-10H,8H2,1-2H3,(H,15,16,17)
InChIKey IGRZXNLKVUEFDM-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Bml 259 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-435)

Biological Description

Alternative Names N-(5-Isopropylthiazol-2-yl)phenylacetamide
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 16760027
Scientific Background Bml 259 is a potent inhibitor of cyclin-dependent kinase 5 (Cdk5)/p25, with additional inhibitory activity against Cdk2/cyclin E. Cdk5 is a critical regulator of neuronal development, synaptic function, and neurodegeneration. Aberrant activation of Cdk5, particularly through its association with p25, has been implicated in tau hyperphosphorylation and neuronal death in Alzheimer’s disease. Bml 259 is used in neuroscience to explore the pathological role of Cdk5/p25 signaling and to evaluate neuroprotective strategies targeting kinase dysregulation.
References 1. Kaźmierczak A., Czapski G.A., Adamczyk A., Gajkowska B., & Strosznajder J.B. (2011) Neurochem. Int. 58(2): 206–214.

Product Images

<p>Chemical structure of BML 259 (SIH-435), a CDK5/p25 kinase inhibitor. CAS #: 267654-00-2. Molecular Formula: C14H16N2OS. Molecular Weight: 260.4 g/mol.</p>

Chemical structure of BML 259 (SIH-435), a CDK5/p25 kinase inhibitor. CAS #: 267654-00-2. Molecular Formula: C14H16N2OS. Molecular Weight: 260.4 g/mol.

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