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| Product Name | Bml 277 |
| Description |
CHK2 kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 516480-79-8 |
| Molecular Formula | C20H14ClN3O2 |
| Molecular Weight | 363.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | C1=CC(=CC=C1C2=NC3=C(N2)C=CC(=C3)C(=O)N)OC4=CC=C(C=C4)Cl |
| InChI | InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24) |
| InChIKey | UXGJAOIJSROTTN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Bml 277 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-436) |
Biological Description
| Alternative Names | Chk2 Inhibitor II, Chk2 Inhibitor II hydrate, 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 9969021 |
| Scientific Background | Bml 277 is a highly selective inhibitor of checkpoint kinase 2 (Chk2), a key component of the DNA damage response pathway. In neuroscience, Chk2 is studied for its role in neuronal apoptosis and genomic stability under stress conditions. Bml 277 is used to investigate the contribution of Chk2 signaling to neurodegenerative processes, particularly in models of oxidative stress, ischemia, and neuroinflammation. Its selectivity makes it a valuable tool for dissecting DNA repair mechanisms and their impact on neuronal survival. |
| References | 1. Pereg Y., et al. (2006) Mol. Cell Biol. 26(18): 6819–6831. |
Product Images
Chemical structure of BML 277 (SIH-436), a CHK2 kinase inhibitor. CAS #: 516480-79-8. Molecular Formula: C20H14ClN3O2. Molecular Weight: 363.8 g/mol.
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