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| Product Name | Brefeldin A |
| Description |
GEF inhibitor |
| Purity | >98% |
| CAS No. | 20350-15-6 |
| Molecular Formula | C16H24O4 |
| Molecular Weight | 280.36 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 10 mM in ethanol and to 50 mM in DMSO |
| Source | Synthetic |
| Appearance | White Crystalline Solid |
| SMILES | C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C/C(=O)O1)O)O |
| InChI | InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+, |
| InChIKey | KQNZDYYTLMIZCT-PNFJWZTBSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects Hazard Phrases: H301 Precautionary Phrases: P301 + P310 |
| Cite This Product | Brefeldin A (StressMarq Biosciences, Canada, Cat # SIH-225) |
Biological Description
| Alternative Names | Cyanaein |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5287620 |
| Scientific Background | Brefeldin A is a fungal metabolite that inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus by targeting GTP-exchange factors for Arf1. In neuroscience, it is used to study protein trafficking and ER stress, both of which are implicated in neurodegenerative diseases such as ALS and Parkinson’s disease. Its reversible inhibition allows for controlled investigation of intracellular transport mechanisms. |
| References |
1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080. 2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108. |
Product Images
Chemical structure of Brefeldin A (SIH-225), a Inhibits intracellular transport. CAS #: 20350-15-6. Molecular Formula: C16H24O4. Molecular Weight: 280.36 g/mol.
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Based on validation through cited publications.