Brefeldin A

GEF inhibitor

Catalog No. SIH-225

5.00 out of 5 based on 1 customer rating
CAS No. 20350-15-6
Molecular Formula C16H24O4
SKU: SIH-225 Categories: ,

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SIH-225_Brefeldin_A_Chemical_Structure.png
Product Name Brefeldin A
Description

GEF inhibitor

Purity >98%
CAS No. 20350-15-6
Molecular Formula C16H24O4
Molecular Weight 280.36
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source Synthetic
Appearance White Crystalline Solid
SMILES C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C/C(=O)O1)O)O
InChI InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,
InChIKey KQNZDYYTLMIZCT-PNFJWZTBSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R68- Possible risk of irreversible effects
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
Cite This Product Brefeldin A (StressMarq Biosciences, Canada, Cat # SIH-225)

Biological Description

Alternative Names Cyanaein
Research Areas Apoptosis, Cancer
PubChem ID 5287620
Scientific Background Brefeldin A is a fungal metabolite that inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus by targeting GTP-exchange factors for Arf1. In neuroscience, it is used to study protein trafficking and ER stress, both of which are implicated in neurodegenerative diseases such as ALS and Parkinson’s disease. Its reversible inhibition allows for controlled investigation of intracellular transport mechanisms.
References 1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080.
2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.

Product Images

<p>Chemical structure of Brefeldin A (SIH-225), a Inhibits intracellular transport. CAS #: 20350-15-6. Molecular Formula: C16H24O4. Molecular Weight: 280.36 g/mol.</p>

Chemical structure of Brefeldin A (SIH-225), a Inhibits intracellular transport. CAS #: 20350-15-6. Molecular Formula: C16H24O4. Molecular Weight: 280.36 g/mol.

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