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| Product Name | BRL-50481 |
| Description |
PDE7 inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 433695-36-4 |
| Molecular Formula | C9H12N2O4S |
| Molecular Weight | 244.26 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (40 mg/ml) or Ethanol (5 mg/ml) |
| Source | Synthetic |
| Appearance | Cream solid |
| SMILES | CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)C |
| InChI | InChI=1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3 |
| InChIKey | IFIUFCJFLGCQPH-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | BRL-50481 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-374) |
Biological Description
| Alternative Names | N,N,2-Trimethyl-5-nitro-benzenesulfonamide |
| Research Areas | Neuroscience |
| PubChem ID | 2921148 |
| Scientific Background | BRL-50481 is a selective phosphodiesterase 7 (PDE7) inhibitor that has shown promise in modulating cyclic AMP signaling pathways. PDE7 is expressed in immune and neuronal cells, and its inhibition may reduce neuroinflammation and promote neuroprotection. While initially studied for its role in osteoporosis, BRL-50481 is gaining interest in neurodegenerative disease research for its ability to regulate intracellular signaling cascades involved in neuronal survival and plasticity. Its specificity makes it a valuable tool for dissecting PDE7-mediated mechanisms in brain health. |
| References |
1. Smith J., et al. (2004) Molecular Biology Pharmacology. 66(6): 1679-89. 2. Pekkinen M., et al. (2008) Bone. 43(1): 84-91. |
Product Images
Chemical structure of BRL-50481 (SIH-374), a PDE7 inhibitor. CAS #: 433695-36-4. Molecular Formula: C9H12N2O4S. Molecular Weight: 244.26 g/mol.
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