Camostat mesylate

Serine protease inhibitor

Catalog No. SIH-585

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CAS No. 59721-29-8
Molecular Formula C20H22N4O5·CH3SO3H
SKU: SIH-585 Categories: ,

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SIH-585-Camostat-mesylate-Chemical-Structure.png
Product Name Camostat mesylate
Description

Serine protease inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 59721-29-8
Molecular Formula C20H22N4O5·CH3SO3H
Molecular Weight 494.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (50 mg/mL) or Water (50mg/mL)
Source Synthetic
Appearance Off-white powder
SMILES O=C(C2=CC=C(NC(N)=N)C=C2)OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1.CS(=O)(O)=O
InChI InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
InChIKey FSEKIHNIDBATFG-UHFFFAOYSA-N
Safety Phrases General Classification: Warning Hazard statements: H315-H319-H335-H400 Precautionary statements: P261-P273-P305 + P351 + P338
Cite This Product Camostat mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-585)

Biological Description

Alternative Names 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate
Research Areas Cancer, Cell Signaling
PubChem ID 5284360
Scientific Background Camostat mesylate is an orally bioavailable serine protease inhibitor best known for its inhibition of TMPRSS2, a key enzyme facilitating viral entry in respiratory infections such as COVID-19. While its primary research focus lies in infectious disease and fibrosis, Camostat’s modulation of protease activity has implications for neuroinflammation and blood-brain barrier integrity.

Emerging studies suggest potential roles in neurodegenerative disease models where protease dysregulation contributes to pathology. Its anti-fibrotic and anti-inflammatory properties also make it a candidate for repurposing in neurological contexts involving chronic inflammation or glial activation.
References 1. Okuno M., et al. (2002). Front Biosci. 7 (4): d204-218.
2. Hsieh H. P., Hsu, J. T. (2007). Current Pharmaceutical Design. 13 (34): 3531–3542.
3. Kitamura K., Tomita K. (2012). Clinical and Experimental Nephrology. 16 (1): 44–48. 4. Kawase M., Shirato K., van der Hoek L., Taguchi F., Matsuyama S. (2012) J Virol. 86(12): 6537-6545. 5.. Hoffman M., et al. (2020) Cell: https://doi.org/10.1016/j.cell.2020.02.052

Product Images

<p>Chemical structure of Camostat mesylate (SIH-585), a Serine protease inhibitor. CAS #: 59721-29-8. Molecular Formula: C20H22N4O5·CH3SO3H. Molecular Weight: 494.5 g/mol.</p>

Chemical structure of Camostat mesylate (SIH-585), a Serine protease inhibitor. CAS #: 59721-29-8. Molecular Formula: C20H22N4O5·CH3SO3H. Molecular Weight: 494.5 g/mol.

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