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| Product Name | Carfilzomib |
| Description |
20S Proteasome inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 868540-17-4 |
| Molecular Formula | C40H57N5O7 |
| Molecular Weight | 719.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (80 mg/ml), or ethanol (25 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | O=C([C@]1(C)OC1)[C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCC2=CC=CC=C2)NC(CN3CCOCC3)=O)=O)CC(C)C)=O)CC4=CC=CC=C4)=O |
| InChI | 1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H |
| InChIKey | BLMPQMFVWMYDKT-NZTKNTHTSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled. Hazard statements: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Cite This Product | Carfilzomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-544) |
Biological Description
| Alternative Names | (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide, PR-17, Carfilzomib, Kyprolis, Carfilzomib (PR-171), PR-171, UNII-72X6E3J5AR |
| Research Areas | Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors |
| PubChem ID | 11556711 |
| Scientific Background | Carfilzomib is an irreversible proteasome inhibitor that selectively targets the chymotrypsin-like activity of the 20S proteasome. While primarily developed as an anticancer agent, Carfilzomib has relevance in neurodegenerative disease research due to its impact on protein homeostasis. By modulating the ubiquitin-proteasome system, Carfilzomib helps elucidate mechanisms of protein aggregation and clearance, which are central to diseases like Alzheimer’s, Parkinson’s, and ALS. Its role in inducing apoptosis and cell cycle arrest also provides insights into neuronal vulnerability and stress responses. |
Product Images
Chemical structure of Carfilzomib (SIH-544), a 20S Proteasome inhibitor. CAS #: 868540-17-4. Molecular Formula: C40H57N5O7. Molecular Weight: 719.9 g/mol.
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