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| Product Name | Celastrol |
| Description |
Proteasome inhibitor |
| Purity | >98% |
| CAS No. | 34157-83-0 |
| Molecular Formula | C29H38O4 |
| Molecular Weight | 450.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol |
| Source | Synthetic |
| Appearance | Red Powder |
| SMILES | CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O |
| InChI | InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1 |
| InChIKey | KQJSQWZMSAGSHN-JJWQIEBTSA-N |
| Safety Phrases |
Classification: Toxic- Toxic Material Causing Immediate and Serious Toxic Effects Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H301 – Toxic if swallowed Precautionary Statements: P301 + P31 – If Swallowed, immediately call a POISON CENTER or doctor. |
| Cite This Product | Celastrol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-333) |
Biological Description
| Alternative Names | 3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors |
| PubChem ID | 122724 |
| Scientific Background | Celastrol is a potent antioxidant and anti-inflammatory compound that inhibits NFκB and proteasome activity. It induces heat shock response and cytoprotection. In neurodegenerative disease research, Celastrol is investigated for its ability to reduce oxidative stress, modulate inflammation, and enhance cellular resilience in models of Alzheimer's and Parkinson's disease. |
| References |
1. Sethi G., et al. (2007) Blood109: 2727. 2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053. 3. Yang H., et al. (2006) Cancer Res. 66: 4758. |
Product Images
Chemical structure of Celastrol (SIH-333), a Proteasome inhibitor. CAS #: 34157-83-0. Molecular Formula: C29H38O4. Molecular Weight: 450.6 g/mol.
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