Celastrol

Proteasome inhibitor

Catalog No. SIH-333

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CAS No. 34157-83-0
Molecular Formula C29H38O4
SKU: SIH-333 Categories: ,

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SIH-333_Celastrol_Chemical_Structure.png
Product Name Celastrol
Description

Proteasome inhibitor

Purity >98%
CAS No. 34157-83-0
Molecular Formula C29H38O4
Molecular Weight 450.6
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol
Source Synthetic
Appearance Red Powder
SMILES CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O
InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
InChIKey KQJSQWZMSAGSHN-JJWQIEBTSA-N
Safety Phrases Classification: Toxic- Toxic Material Causing Immediate and Serious Toxic Effects
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H301 – Toxic if swallowed
Precautionary Statements:
P301 + P31 – If Swallowed, immediately call a POISON CENTER or doctor.
Cite This Product Celastrol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-333)

Biological Description

Alternative Names 3-​hydroxy-​9β,​13α-​dimethyl-​2-​oxo-​24,​25,​26-​trinoroleana-​1(10),​3,​5,​7-​tetraen-​29-​oic acid, 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors
PubChem ID 122724
Scientific Background Celastrol is a potent antioxidant and anti-inflammatory compound that inhibits NFκB and proteasome activity. It induces heat shock response and cytoprotection. In neurodegenerative disease research, Celastrol is investigated for its ability to reduce oxidative stress, modulate inflammation, and enhance cellular resilience in models of Alzheimer's and Parkinson's disease.
References 1. Sethi G., et al. (2007) Blood109: 2727.
2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053.
3. Yang H., et al. (2006) Cancer Res. 66: 4758.

Product Images

<p>Chemical structure of Celastrol (SIH-333), a Proteasome inhibitor. CAS #: 34157-83-0. Molecular Formula: C29H38O4. Molecular Weight: 450.6 g/mol.</p>

Chemical structure of Celastrol (SIH-333), a Proteasome inhibitor. CAS #: 34157-83-0. Molecular Formula: C29H38O4. Molecular Weight: 450.6 g/mol.

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