Chloroquine diphosphate

Autophagy inhibitor

Catalog No. SIH-405

5.00 out of 5 based on 1 customer rating
CAS No. 50-63-5
Molecular Formula C18H26ClN3·2H3PO4
SKU: SIH-405 Categories: ,

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SIH-405_Chloroquine_diphosphate_Chemical_Structure.png
Product Name Chloroquine diphosphate
Description

Autophagy inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 50-63-5
Molecular Formula C18H26ClN3·2H3PO4
Molecular Weight 515.86
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in water (25mg/mL)
Source Synthetic
Appearance Beige Solid
SMILES C1=CC(=CC2=C1C(=CC=N2)NC(CCCN(CC)CC)C)Cl.O=[P](O)(O)O.O=[P](O)(O)O
InChI InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChIKey QKICWELGRMTQCR-UHFFFAOYSA-N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Chloroquine diphosphate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-405)

Biological Description

Alternative Names N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Research Areas Autophagy, Cancer
PubChem ID 64927
Scientific Background Chloroquine diphosphate is a lysosomotropic agent widely used to inhibit autophagy by preventing lysosomal acidification and autophagosome-lysosome fusion. In neuroscience, chloroquine is employed to study autophagic flux and lysosomal function in neurodegenerative disease models. Impaired autophagy is a hallmark of disorders such as Alzheimer’s and Parkinson’s, where the accumulation of protein aggregates and damaged organelles contributes to neuronal dysfunction. Chloroquine’s ability to modulate autophagy and endolysosomal pathways provides insights into the cellular mechanisms underlying neurodegeneration. Additionally, its anti-inflammatory properties have been explored in the context of neuroinflammation and glial cell regulation.
References 1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14.
2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81.

Product Images

<p>Chemical structure of Chloroquine diphosphate (SIH-405), a Autophagy inhibitor. CAS #: 50-63-5. Molecular Formula: C18H26ClN3·2H3PO4. Molecular Weight: 515.86 g/mol.</p>

Chemical structure of Chloroquine diphosphate (SIH-405), a Autophagy inhibitor. CAS #: 50-63-5. Molecular Formula: C18H26ClN3·2H3PO4. Molecular Weight: 515.86 g/mol.

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