Discovery through Partnership | Excellence through Quality
| Product Name | Chloroquine diphosphate |
| Description |
Autophagy inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 50-63-5 |
| Molecular Formula | C18H26ClN3·2H3PO4 |
| Molecular Weight | 515.86 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in water (25mg/mL) |
| Source | Synthetic |
| Appearance | Beige Solid |
| SMILES | C1=CC(=CC2=C1C(=CC=N2)NC(CCCN(CC)CC)C)Cl.O=[P](O)(O)O.O=[P](O)(O)O |
| InChI | InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4) |
| InChIKey | QKICWELGRMTQCR-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Chloroquine diphosphate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-405) |
Biological Description
| Alternative Names | N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 64927 |
| Scientific Background | Chloroquine diphosphate is a lysosomotropic agent widely used to inhibit autophagy by preventing lysosomal acidification and autophagosome-lysosome fusion. In neuroscience, chloroquine is employed to study autophagic flux and lysosomal function in neurodegenerative disease models. Impaired autophagy is a hallmark of disorders such as Alzheimer’s and Parkinson’s, where the accumulation of protein aggregates and damaged organelles contributes to neuronal dysfunction. Chloroquine’s ability to modulate autophagy and endolysosomal pathways provides insights into the cellular mechanisms underlying neurodegeneration. Additionally, its anti-inflammatory properties have been explored in the context of neuroinflammation and glial cell regulation. |
| References |
1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14. 2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81. |
Product Images
Chemical structure of Chloroquine diphosphate (SIH-405), a Autophagy inhibitor. CAS #: 50-63-5. Molecular Formula: C18H26ClN3·2H3PO4. Molecular Weight: 515.86 g/mol.
Powered by Bioz
StressMarq Biosciences :
Based on validation through cited publications.