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| Product Name | Cycloheximide |
| Description |
Translation inhibitor |
| Purity | >98% |
| CAS No. | 66-81-9 |
| Molecular Formula | C15H23NO4 |
| Molecular Weight | 281.35 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 50 mM in Ethanol and 25 mM in water |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C |
| InChI | InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12 |
| InChIKey | YPHMISFOHDHNIV-FSZOTQKASA-N |
| Safety Phrases |
Classification: Very toxic. May be fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R26/27/28 - Very Toxic by inhalation, in contact with skin and if swallowed R62 - Possible risk of impaired fertility R68- Possible risk of irreversible effects Hazard Phrases: H300-H341-H360D-H411 Precautionary Phrases: P201-P264-P273-P281-P301 + P310-P308 + P313 |
| Cite This Product | Cycloheximide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-247) |
Biological Description
| Alternative Names | 4-{(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}-2,6-piperidinedione |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 6197 |
| Scientific Background | Cycloheximide is a selective inhibitor of eukaryotic protein synthesis that blocks tRNA binding and release from ribosomes. It is widely used in neuroscience to study protein turnover, synaptic plasticity, and apoptosis. Cycloheximide-induced inhibition of translation provides insights into the role of de novo protein synthesis in memory formation and neurodegeneration. |
| References | 1. Obrig T.G., et al. (1971) J Biol Chem. 246:174. |
Product Images
Chemical structure of Cycloheximide (SIH-247), a Translation inhibitor. CAS #: 66-81-9. Molecular Formula: C15H23NO4. Molecular Weight: 281.35 g/mol.
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