Cyclosporine

Immunosuppressant

Catalog No. SIH-201

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CAS No. 59865-13-3
Molecular Formula C62H111N11O12
SKU: SIH-201 Categories: ,

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SIH-201_Cyclosporine_Chemical_Structure.png
Product Name Cyclosporine
Description

Immunosuppressant

Purity >99%
CAS No. 59865-13-3
Molecular Formula C62H111N11O12
Molecular Weight 1202.63
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO, 50 mM in ethanol
Source Synthetic
Appearance White Solid
SMILES CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(
InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(
InChIKey PMATZTZNYRCHOR-IMVLJIQESA-N
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
R45 - May cause cancer
R62 - Possible risk of impaired fertility
R68 - Possible risk of irreversible effects
Hazard Phrases:
H302-H350-H360
Precautionary Phrases:
P201-P308 + P313
Cite This Product Cyclosporine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-201)

Biological Description

Alternative Names (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, Cyclosporin A
Research Areas Apoptosis, Cancer
PubChem ID 5284373
Scientific Background Cyclosporine A is a cyclic peptide immunosuppressant that inhibits calcineurin, thereby preventing the activation of NF-AT and downstream T-cell responses. In neuroscience, cyclosporine has been investigated for its neuroprotective effects, particularly in models of traumatic brain injury, stroke, and neurodegenerative diseases. By inhibiting mitochondrial permeability transition pore (mPTP) opening, cyclosporine helps preserve mitochondrial integrity and prevent apoptosis in neurons. Its ability to modulate calcium signaling and reduce oxidative stress makes it a promising agent for protecting neural tissue under pathological conditions.
References 1. Heitman J., et al. (1992) New Biol. 4:448.
2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.

Product Images

<p>Chemical structure of Cyclosporine (SIH-201), a Inhibits mitochondrial permeability pore opening. CAS #: 59865-13-3. Molecular Formula: C62H111N11O12 . Molecular Weight: 1202.63 g/mol.</p>

Chemical structure of Cyclosporine (SIH-201), a Inhibits mitochondrial permeability pore opening. CAS #: 59865-13-3. Molecular Formula: C62H111N11O12 . Molecular Weight: 1202.63 g/mol.

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