Cytochalasin D

Actin polymerization inhibitor

Catalog No. SIH-241

5.00 out of 5 based on 1 customer rating
CAS No.
Molecular Formula
SKU: SIH-241 Categories: ,

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SIH-241_Cytochalasin_D_Chemical_Structure.png
Product Name Cytochalasin D
Description

Actin polymerization inhibitor

Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Solubility Soluble to 10 mM in ethanol and to 50 mM in DMSO
Appearance White Solid
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62 - Possible risk of impaired fertility
R68 - Possible risk of irreversible effects
Hazard Phrases:
H300-H361
Precautionary Phrases:
P264-P281-P301 + P310
Cite This Product Cytochalasin D (StressMarq Biosciences, Canada, Cat # SIH-241)

Biological Description

Alternative Names (3S,3aR,4S,6S,6aR,7E,10S,12S,13E,15R,15aR)-3-Benzyl-6-hydroxy-4,10,12-trimethyl-5-methylene-1-oxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate, Zygosporin A
Scientific Background Cytochalasin D binds to actin filaments and inhibits their polymerization and elongation, leading to changes in cellular morphology and apoptosis. In neuroscience, it is widely used to study cytoskeletal dynamics, synaptic plasticity, and neuronal migration. Its ability to disrupt actin networks makes it a powerful agent for probing the role of the cytoskeleton in neurodevelopment and neurodegeneration.
References 1.  Haidle A., and Myers A. (2004) Proc Natl Acad Sci. 101(33): 12048-12053.
2. Ornelles et al., (1986) Mol Cell Biol. 6(5): 1650-1662.

Product Images

<p>Chemical structure of Cytochalasin D (SIH-241), a Disrupts actin filaments. CAS #: 22144-77-0. Molecular Formula: C30H37NO6. Molecular Weight: 507.63 g/mol.</p>

Chemical structure of Cytochalasin D (SIH-241), a Disrupts actin filaments. CAS #: 22144-77-0. Molecular Formula: C30H37NO6. Molecular Weight: 507.63 g/mol.

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