CZC 54252 Hydrochloride

LRRK2 inhibitor

Catalog No. SIH-439

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CAS No. 1191911-27-9, 1330003-04-7
Molecular Formula C22H26Cl2N6O4S
SKU: SIH-439 Categories: ,

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SIH-439_CZC-54252_Hydrochloride_Chemical_Structure.png
Product Name CZC 54252 Hydrochloride
Description

LRRK2 inhibitor

Purity >98%
CAS No. 1191911-27-9, 1330003-04-7
Molecular Formula C22H26Cl2N6O4S
Molecular Weight 541.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance Yellow solid
SMILES COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl
InChI InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
InChIKey KWCBHUPLQMUKAF-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product CZC 54252 Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-439)

Biological Description

Alternative Names N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide hydrochloride
Research Areas Cell Signaling, Neurodegeneration, Neuroscience, Multiple System Atrophy
Scientific Background CZC 54252 Hydrochloride is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a kinase genetically linked to familial and sporadic Parkinson’s disease. LRRK2 mutations are associated with altered kinase activity, leading to impaired autophagy, mitochondrial dysfunction, and neuroinflammation. CZC 54252 is widely used in Parkinson’s disease research to study the effects of LRRK2 inhibition on neuronal survival, protein clearance, and inflammatory responses. Its selectivity and potency make it a valuable tool for validating LRRK2 as a therapeutic target in neurodegeneration.
References 1. Kramer T., Lo Monte F., Göring S., Okala Amombo G.M., & Schmidt B. (2012) ACS Chem. Neuro. 3(3): 151–160.

Product Images

<p>Chemical structure of CZC 54252 Hydrochloride (SIH-439), a LRRK2 inhibitor. CAS #: 1191911-27-9. Molecular Formula: C22H26Cl2N6O4S. Molecular Weight: 541.5 g/mol.</p>

Chemical structure of CZC 54252 Hydrochloride (SIH-439), a LRRK2 inhibitor. CAS #: 1191911-27-9. Molecular Formula: C22H26Cl2N6O4S. Molecular Weight: 541.5 g/mol.

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