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| Product Name | Dasatinib |
| Description |
Kinase inhibitor |
| Purity | >98% |
| CAS No. | 302962-49-8 |
| Molecular Formula | C22H26ClN7O2S |
| Molecular Weight | 488.0 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ) |
| Source | Synthetic |
| Appearance | Crystalline solid |
| SMILES | C1=C(SC(=N1)NC2=CC(=NC(=N2)C)N3CCN(CC3)CCO)C(=O)NC4=C(C=CC=C4Cl)C |
| InChI | InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) |
| InChIKey | ZBNZXTGUTAYRHI-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute Toxicity: Oral, Category 3 Toxic To Reproduction, Category 1B Target Organ Systemic Toxicity (single exposure), Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301: Toxic if swallowed. H360: May damage fertility or the unborn child. H370: Causes damage to organs {uterus, testicles,ovaries}. H373: May cause damage to {uterus, testicles,ovaries} through prolonged or repeated exposure. Precautionary statements: P264: Wash {hands} thoroughly after handling. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330: Rinse mouth. P308+313: IF exposed or concerned: Get medical attentiodvice. P312: Call a {POISON CENTER/doctor/...} if you feel unwell. P314: Get medical attentiodvice if you feel unwell. |
| Cite This Product | Dasatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-440) |
Biological Description
| Alternative Names | N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 3062316 |
| Scientific Background | Dasatinib is a dual Src and Abl kinase inhibitor with significantly greater potency against BCR-ABL than imatinib. In neuroscience, Src family kinases are involved in synaptic signaling, neuroinflammation, and blood-brain barrier integrity. Dasatinib is used to investigate the role of tyrosine kinase signaling in neurodegenerative diseases and has shown potential in modulating microglial activation and reducing neuroinflammatory responses. Its ability to cross the blood-brain barrier and inhibit multiple kinases makes it a promising candidate for repurposing in neurodegenerative and neuroinflammatory conditions. |
| References | 1. Benjamini O., et al. (2014) Am. J. Hematology. 89(3): 282–287. |
Product Images
Chemical structure of Dasatinib (SIH-440), a Src and Bcr/Abl kinase inhibitor. CAS #: 302962-49-8. Molecular Formula: C22H26ClN7O2S. Molecular Weight: 488 g/mol.
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