Dasatinib

Kinase inhibitor

Catalog No. SIH-440

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CAS No. 302962-49-8
Molecular Formula C22H26ClN7O2S
SKU: SIH-440 Categories: ,

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SIH-440_Dasatinib_Chemical_Structure.png
Product Name Dasatinib
Description

Kinase inhibitor

Purity >98%
CAS No. 302962-49-8
Molecular Formula C22H26ClN7O2S
Molecular Weight 488.0
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly )
Source Synthetic
Appearance Crystalline solid
SMILES C1=C(SC(=N1)NC2=CC(=NC(=N2)C)N3CCN(CC3)CCO)C(=O)NC4=C(C=CC=C4Cl)C
InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChIKey ZBNZXTGUTAYRHI-UHFFFAOYSA-N
Safety Phrases Classification:
Acute Toxicity: Oral, Category 3
Toxic To Reproduction, Category 1B
Target Organ Systemic Toxicity (single exposure), Category 2
Target Organ Systemic Toxicity (repeated exposure), Category 2

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H301: Toxic if swallowed.
H360: May damage fertility or the unborn child.
H370: Causes damage to organs {uterus, testicles,ovaries}.
H373: May cause damage to {uterus, testicles,ovaries} through prolonged or repeated exposure.

Precautionary statements:
P264: Wash {hands} thoroughly after handling.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P260: Do not breathe {dust/fume/gas/mist/vapours/spray}.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330: Rinse mouth.
P308+313: IF exposed or concerned: Get medical attentiodvice.
P312: Call a {POISON CENTER/doctor/...} if you feel unwell.
P314: Get medical attentiodvice if you feel unwell.
Cite This Product Dasatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-440)

Biological Description

Alternative Names N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 3062316
Scientific Background Dasatinib is a dual Src and Abl kinase inhibitor with significantly greater potency against BCR-ABL than imatinib. In neuroscience, Src family kinases are involved in synaptic signaling, neuroinflammation, and blood-brain barrier integrity. Dasatinib is used to investigate the role of tyrosine kinase signaling in neurodegenerative diseases and has shown potential in modulating microglial activation and reducing neuroinflammatory responses. Its ability to cross the blood-brain barrier and inhibit multiple kinases makes it a promising candidate for repurposing in neurodegenerative and neuroinflammatory conditions.
References 1. Benjamini O., et al. (2014) Am. J. Hematology. 89(3): 282–287.

Product Images

<p>Chemical structure of Dasatinib (SIH-440), a Src and Bcr/Abl kinase inhibitor. CAS #: 302962-49-8. Molecular Formula: C22H26ClN7O2S. Molecular Weight: 488 g/mol.</p>

Chemical structure of Dasatinib (SIH-440), a Src and Bcr/Abl kinase inhibitor. CAS #: 302962-49-8. Molecular Formula: C22H26ClN7O2S. Molecular Weight: 488 g/mol.

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