DBeQ

p97 inhibitor

Catalog No. SIH-334

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CAS No.
Molecular Formula C22H20N4
SKU: SIH-334 Categories: ,

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SIH-334_DBeQ_Chemical_Structure.png
Product Name DBeQ
Description

p97 inhibitor

Purity >98%
Molecular Formula C22H20N4
Molecular Weight 340.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO
Source Synthetic
Appearance Yellow Powder
SMILES C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4
InChI InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
InChIKey QAIMUUJJAJBPCL-UHFFFAOYSA-N
Safety Phrases Classification: Toxic Material Causing other toxic effects- moderate eye irritant.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
Precautionary Statements:
P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product DBeQ (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-334)

Biological Description

Alternative Names N,N'-Dibenzyl-2,4-quinazolinediamine, JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine, N2,N4-Bis(phenylmethyl)-2,4-quinazo­linediamine
Research Areas Apoptosis, Cancer
PubChem ID 676352
Scientific Background DBeQ is a selective and reversible inhibitor of the AAA-ATPase p97, which is involved in ubiquitin-dependent protein clearance. It is cell permeable and used in neuroscience to study protein degradation pathways, ER stress responses, and neurodegenerative mechanisms linked to impaired proteostasis.
References 1. Chou T.F., et al. 2011 PNAS 108:4834.

Product Images

<p>Chemical structure of DBeQ (SIH-334), a p97 inhibitor. CAS #: N/A. Molecular Formula: C22H20N4. Molecular Weight: 340.4 g/mol.</p>

Chemical structure of DBeQ (SIH-334), a p97 inhibitor. CAS #: N/A. Molecular Formula: C22H20N4. Molecular Weight: 340.4 g/mol.

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