DBeQ

Name: DBeQ
SKU: SIH-334
Availability: InStock

p97 inhibitor

Catalog No. SIH-334

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CAS No.
Molecular Formula	C22H20N4

SKU: SIH-334 Categories: Inhibitor, Small Molecules

Product Name	DBeQ
Description	p97 inhibitor
Purity	>98%
Molecular Formula	C₂₂H₂₀N₄
Molecular Weight	340.4
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 25 mg/ml DMSO
Source	Synthetic
Appearance	Yellow Powder
SMILES	C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4
InChI	InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
InChIKey	QAIMUUJJAJBPCL-UHFFFAOYSA-N
Safety Phrases	Classification: Toxic Material Causing other toxic effects- moderate eye irritant. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed Precautionary Statements: P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product	DBeQ (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-334)

Alternative Names	N,N'-Dibenzyl-2,4-quinazolinediamine, JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine, N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Research Areas	Apoptosis, Cancer
PubChem ID	676352
Scientific Background	DBeQ is a selective and reversible inhibitor of the AAA-ATPase p97, which is involved in ubiquitin-dependent protein clearance. It is cell permeable and used in neuroscience to study protein degradation pathways, ER stress responses, and neurodegenerative mechanisms linked to impaired proteostasis.
References	1. Chou T.F., et al. 2011 PNAS 108:4834.

Chemical structure of DBeQ (SIH-334), a p97 inhibitor. CAS #: N/A. Molecular Formula: C22H20N4. Molecular Weight: 340.4 g/mol.

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