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| Product Name | Decitabine |
| Description |
DNA hypomethylation agent |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 2353-33-5 |
| Molecular Formula | C8H12N4O4 |
| Molecular Weight | 228.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 25 mg/ml DMSO, 11 mg/ml Water or Ethanol |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O |
| InChI | InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1 |
| InChIKey | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
| Safety Phrases |
Classification: Harmful – May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H341 – Suspected of causing genetic defects H360 – May damage fertility or the unborn child Precautionary Statements: P280 – Wear protective gloves/protective clothing/ eye protection/ face protection P308+313 – If exposed or concerned: Get Medical Advise/Attention |
| Cite This Product | Decitabine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-352) |
Biological Description
| Alternative Names | 5-Aza-2'-deoxycytidine; NSC-127716, 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one |
| Research Areas | Cancer, Cell Signaling |
| PubChem ID | 451668 |
| Scientific Background | Decitabine is a DNA methyltransferase inhibitor that induces hypomethylation of DNA, leading to the reactivation of silenced genes. While primarily used as an antineoplastic agent in hematologic malignancies, its epigenetic modulation capabilities have implications in neuroscience. Decitabine has been shown to enhance neuronal plasticity, promote neurogenesis, and influence memory-related gene expression. These properties make it a valuable compound for exploring the role of DNA methylation in neurodevelopmental and neurodegenerative disorders. Its ability to modulate gene expression without altering the DNA sequence positions Decitabine as a powerful tool in epigenetic research related to brain function and disease. |
| References |
1. Bender C.M., et al. (1998) Cancer Res. 58: 95. 2. El-Serafi A.T., et al. (2011) Differentiation 81: 35. |
Product Images
Chemical structure of Decitabine (SIH-352), a DNA hypomethylation agent. CAS #: 2353-33-5. Molecular Formula: C8H12N4O4. Molecular Weight: 228.2 g/mol.
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