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| Product Name | Difluoromethylornithine |
| Description |
ODC Inhibitor |
| Purity | >98% |
| CAS No. | 70052-12-9 |
| Molecular Formula | C6H12F2N2O2•HCl |
| Molecular Weight | 218.63 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 75 mM in water |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | FC(F)NC(CCCN)C(O)=O |
| InChI | InChI=1S/C6H12F2N2O2/c7-6(8)10-4(5(11)12)2-1-3-9/h4,6,10H,1-3,9H2,(H,11,12)/t4-/m0/s1 |
| InChIKey | LDLGBNXSBZFATB-BYPYZUCNSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Difluoromethylornithine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-200) |
Biological Description
| Alternative Names | N2-(Difluoromethyl)ornithine, DFMO, Eflornithine |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 3009 |
| Scientific Background | Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, a key enzyme in polyamine biosynthesis. While primarily studied for its anti-cancer, anti-parasitic, and anti-angiogenic properties, DFMO has emerging relevance in neurodegenerative disease research. Polyamines are implicated in neuronal growth, differentiation, and synaptic plasticity, but their dysregulation contributes to neurotoxicity and oxidative stress. By modulating polyamine levels, DFMO may help mitigate excitotoxicity and inflammation in neurodegenerative conditions such as Alzheimer's disease and Huntington's disease. Its potential to reduce neuronal apoptosis and modulate neuroinflammation positions DFMO as a candidate for therapeutic intervention in neurodegeneration. |
| References | 1. Malhotra B., Noveck R., Behr D., Palmisano M. (2001) J Clin Pharmacol. 41: 972-978. |
Product Images
Chemical structure of Difluoromethylornithine (SIH-200), a Inhibits polyamine biosynthesis. CAS #: 70052-12-9. Molecular Formula: C6H12F2N2O2 * HCl. Molecular Weight: 218.63 g/mol.
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