Difluoromethylornithine

ODC Inhibitor

Catalog No. SIH-200

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CAS No. 70052-12-9
Molecular Formula C6H12F2N2O2•HCl
SKU: SIH-200 Categories: ,

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SIH-200_Difluoromethylornithine_Chemical_Structure.png
Product Name Difluoromethylornithine
Description

ODC Inhibitor

Purity >98%
CAS No. 70052-12-9
Molecular Formula C6H12F2N2O2•HCl
Molecular Weight 218.63
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 75 mM in water
Source Synthetic
Appearance White Solid
SMILES FC(F)NC(CCCN)C(O)=O
InChI InChI=1S/C6H12F2N2O2/c7-6(8)10-4(5(11)12)2-1-3-9/h4,6,10H,1-3,9H2,(H,11,12)/t4-/m0/s1
InChIKey LDLGBNXSBZFATB-BYPYZUCNSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Difluoromethylornithine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-200)

Biological Description

Alternative Names N2-(Difluoromethyl)ornithine, DFMO, Eflornithine
Research Areas Apoptosis, Cancer
PubChem ID 3009
Scientific Background Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, a key enzyme in polyamine biosynthesis. While primarily studied for its anti-cancer, anti-parasitic, and anti-angiogenic properties, DFMO has emerging relevance in neurodegenerative disease research. Polyamines are implicated in neuronal growth, differentiation, and synaptic plasticity, but their dysregulation contributes to neurotoxicity and oxidative stress. By modulating polyamine levels, DFMO may help mitigate excitotoxicity and inflammation in neurodegenerative conditions such as Alzheimer's disease and Huntington's disease. Its potential to reduce neuronal apoptosis and modulate neuroinflammation positions DFMO as a candidate for therapeutic intervention in neurodegeneration.
References 1. Malhotra B., Noveck R., Behr D., Palmisano M. (2001) J Clin Pharmacol. 41: 972-978.

Product Images

<p>Chemical structure of Difluoromethylornithine (SIH-200), a Inhibits polyamine biosynthesis. CAS #: 70052-12-9. Molecular Formula: C6H12F2N2O2 * HCl. Molecular Weight: 218.63 g/mol.</p>

Chemical structure of Difluoromethylornithine (SIH-200), a Inhibits polyamine biosynthesis. CAS #: 70052-12-9. Molecular Formula: C6H12F2N2O2 * HCl. Molecular Weight: 218.63 g/mol.

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