DMPQ Dihydrochloride

PDGFRβ kinase inhibitor

Catalog No. SIH-441

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CAS No. 137206-97-4
Molecular Formula C16H16ClN2O2
SKU: SIH-441 Categories: ,

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SIH-441_DMPQ_Dihydrochloride_Chemical_Structure.png
Product Name DMPQ Dihydrochloride
Description

PDGFRβ kinase inhibitor

Purity >98% (HPLC)
CAS No. 137206-97-4
Molecular Formula C16H16ClN2O2
Molecular Weight 339.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in water
Source Synthetic
Appearance White to beige solid
SMILES C1=CC(=CC=N1)C2=CC3=C(N=C2)C=C(C=C3OC)OC
InChI InChI=1S/C16H14N2O2.2ClH/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11;;/h3-10H,1-2H3;2*1H
InChIKey YBBAOKYVJCNJIV-UHFFFAOYSA-N
Safety Phrases Classification:
Acute toxicity, Oral (Category 4)

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H302 Harmful if swallowed.
Cite This Product DMPQ Dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-441)

Biological Description

Alternative Names 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 45073427
Scientific Background DMPQ Dihydrochloride is a potent and selective inhibitor of platelet-derived growth factor receptor beta (PDGFRβ) tyrosine kinase. In neuroscience, PDGFRβ signaling is involved in neurovascular function, blood-brain barrier maintenance, and glial cell regulation. DMPQ is used to study the role of PDGFRβ in neuroinflammation, pericyte function, and neurovascular remodeling in diseases such as Alzheimer’s and stroke. Its high selectivity over other kinases makes it a valuable tool for dissecting PDGFRβ-mediated pathways in the central nervous system.
References 1. Dolle R.E., et al. (1994) J. Med. Chem. 37(17): 2627–2629.

Product Images

<p>Chemical structure of DMPQ Dihydrochloride (SIH-441), a PDGFRbeta kinase inhibitor. CAS #: 137206-97-4. Molecular Formula: C16H16ClN2O2. Molecular Weight: 339.2 g/mol.</p>

Chemical structure of DMPQ Dihydrochloride (SIH-441), a PDGFRbeta kinase inhibitor. CAS #: 137206-97-4. Molecular Formula: C16H16ClN2O2. Molecular Weight: 339.2 g/mol.

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