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| Product Name | DMPQ Dihydrochloride |
| Description |
PDGFRβ kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 137206-97-4 |
| Molecular Formula | C16H16ClN2O2 |
| Molecular Weight | 339.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in water |
| Source | Synthetic |
| Appearance | White to beige solid |
| SMILES | C1=CC(=CC=N1)C2=CC3=C(N=C2)C=C(C=C3OC)OC |
| InChI | InChI=1S/C16H14N2O2.2ClH/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11;;/h3-10H,1-2H3;2*1H |
| InChIKey | YBBAOKYVJCNJIV-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. |
| Cite This Product | DMPQ Dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-441) |
Biological Description
| Alternative Names | 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 45073427 |
| Scientific Background | DMPQ Dihydrochloride is a potent and selective inhibitor of platelet-derived growth factor receptor beta (PDGFRβ) tyrosine kinase. In neuroscience, PDGFRβ signaling is involved in neurovascular function, blood-brain barrier maintenance, and glial cell regulation. DMPQ is used to study the role of PDGFRβ in neuroinflammation, pericyte function, and neurovascular remodeling in diseases such as Alzheimer’s and stroke. Its high selectivity over other kinases makes it a valuable tool for dissecting PDGFRβ-mediated pathways in the central nervous system. |
| References | 1. Dolle R.E., et al. (1994) J. Med. Chem. 37(17): 2627–2629. |
Product Images
Chemical structure of DMPQ Dihydrochloride (SIH-441), a PDGFRbeta kinase inhibitor. CAS #: 137206-97-4. Molecular Formula: C16H16ClN2O2. Molecular Weight: 339.2 g/mol.
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