Doramapimod

p38 MAP kinase inhibitor

Catalog No. SIH-442

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CAS No. 285983-48-4
Molecular Formula C31H37N5O3
SKU: SIH-442 Categories: ,

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SIH-442_Doramapimod_Chemical_Structure.png
Product Name Doramapimod
Description

p38 MAP kinase inhibitor

Purity >99% (HPLC)
CAS No. 285983-48-4
Molecular Formula C31H37N5O3
Molecular Weight 527.7
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO
Source Synthetic
Appearance White solid
SMILES C2=CC(=C1C=CC=CC1=C2NC(NC3=CC(=N[N]3C4=CC=C(C=C4)C)C(C)(C)C)=O)OCCN5CCOCC5
InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
InChIKey MVCOAUNKQVWQHZ-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Doramapimod (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-442)

Biological Description

Alternative Names JNK Inhibitor XVII, BIRB796, 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 156422
Scientific Background Doramapimod is a highly potent and selective inhibitor of p38α mitogen-activated protein kinase (MAPK), a key regulator of inflammatory signaling. In neurodegenerative disease research, p38α MAPK is implicated in microglial activation, cytokine production, and neuronal stress responses. Doramapimod is used to explore the therapeutic potential of p38α inhibition in reducing neuroinflammation and protecting against neuronal damage in conditions such as Alzheimer’s disease, ALS, and multiple sclerosis.
References 1. Pargellis C., et al. (2002). Nat Structural Biol. 9(4): 268–272.

Product Images

<p>Chemical structure of Doramapimod (SIH-442), a p38 MAP kinase inhibitor. CAS #: 285983-48-4. Molecular Formula: C31H37N5O3. Molecular Weight: 527.7 g/mol.</p>

Chemical structure of Doramapimod (SIH-442), a p38 MAP kinase inhibitor. CAS #: 285983-48-4. Molecular Formula: C31H37N5O3. Molecular Weight: 527.7 g/mol.

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