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| Product Name | Dorsomorphin |
| Description |
AMPK kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 866405-64-3 |
| Molecular Formula | C24H25N5O |
| Molecular Weight | 399.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (4 mg/ml, warm) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3 |
| InChI | InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 |
| InChIKey | XHBVYDAKJHETMP-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Dermal (Category 4), H312 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well - ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| Cite This Product | Dorsomorphin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-443) |
Biological Description
| Alternative Names | AMPK Inhibitor, Compound C, 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 11524144 |
| Scientific Background | Dorsomorphin is a potent and selective and reversible inhibitor of AMP-kinase, doing so in an ATP-competitive manner. It is also a selective inhibitor of Bone morphogenetic protein (BMP) signaling. |
| References |
1. Vucicevic L., et al. (2011) Autophagy 7(1): 40–50. 2. Yu P.B., et al. (2008). Nat. Chem. Biol. 4(1): 33–41. |
Product Images
Chemical structure of Dorsomorphin (SIH-443), a AMPK kinase inhibitor. CAS #: 866405-64-3. Molecular Formula: C24H25N5O. Molecular Weight: 399.5 g/mol.
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