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| Product Name | Dovitinib |
| Description |
FGFR3 inhibitor |
| Purity | >98% |
| CAS No. | 405169-16-6 |
| Molecular Formula | C21H21FN6O |
| Molecular Weight | 392.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO |
| Source | Synthetic |
| Appearance | Crystalline solid |
| SMILES | CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N |
| InChI | InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3/b20-18- |
| InChIKey | KCOYQXZDFIIGCY-ZZEZOPTASA-N |
| Safety Phrases |
Classification: Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 2 Target Organ Systemic Toxicity (single exposure), Category 3 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation. Precautionary statements: P302+352: IF ON SKIN: Wash with plenty of soap and water. P332+313: If skin irritation occurs, get medical advice/attention. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+313: If eye irritation persists, get medical advice/attention. P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312: Call a {POISON CENTER/doctor/...} if you feel unwell. |
| Cite This Product | Dovitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-500) |
Biological Description
| Alternative Names | 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone |
| Research Areas | Cell Signaling |
| PubChem ID | 9886808 |
| Scientific Background | Dovitinib is a multi-targeted receptor tyrosine kinase inhibitor with activity against FLT-3, c-KIT, VEGFR, PDGFRβ, and CSF-1R. While primarily investigated for its anti-cancer properties, Dovitinib's inhibition of VEGFR and PDGFRβ has implications for neurovascular health and neuroinflammation. These pathways are increasingly recognized in the pathophysiology of neurodegenerative diseases, including Alzheimer's and Parkinson's. By modulating angiogenic and inflammatory signaling, Dovitinib may offer neuroprotective benefits and serve as a tool for studying neurovascular dysfunction in disease models. |
| References | 1. Konecny G.E., et al. (2013) Mol. Cancer Ther. 12(5): 632–642. |
Product Images
Chemical structure of Dovitinib (SIH-500), a FGFR3 inhibitor. CAS #: 405169-16-6. Molecular Formula: C21H21FN6O. Molecular Weight: 392.4 g/mol.
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