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| Product Name | Dyclonine HCl |
| Description |
Neuroprotection |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 536-43-6 |
| Molecular Formula | C18H27NO2 • HCl |
| Molecular Weight | 325.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in water (25 mg/ml); or DMSO (20 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.Cl |
| InChI | InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H |
| InChIKey | KNZADIMHVBBPOA-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Danger. GHS Hazard Statements: H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H335 (97.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Precautionary Statement Codes,: P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 |
| Cite This Product | Dyclonine HCl (StressMarq Biosciences | Victoria, BC CANADA | Catalog# SIH-638) |
Biological Description
| Alternative Names | 4'-Butoxy-3-piperidinopropiophenone, hydrochloride; dyclocaine |
| Research Areas | Cancer, Ion Channels, Neuroscience, Neurotransmission, Transient Receptor Potential (TRP) Channels |
| PubChem ID | 68304 |
| Scientific Background | This topical anesthetic, traditionally used for oral and pharyngeal analgesia¹, also exhibits several mechanisms relevant to neuronal health. It enhances mitochondrial function in neurons, increasing respiratory capacity and providing protection against stressors associated with neurodegenerative disorders². The compound inhibits the aldehyde dehydrogenase isoform ALDH3A1, leading to the accumulation of 4‑hydroxynonenal; in cancer models, this sensitizes head and neck squamous cell carcinoma cells to the cystine‑glutamate antiporter inhibitor sulfasalazine³. Notably, it rescues frataxin deficiency in animal models and in buccal cells from patients with Friedreich’s ataxia⁴, suggesting therapeutic potential in mitochondrial neurodegeneration. In cancer cells, it also enhances the cytotoxicity of the proteasome inhibitors MG‑132⁵ and bortezomib⁶. |
| References |
H Groeben et al., Anesthesiology (2001) 94:423 HV Boglarka et al., iScience (2020) 23:100931 S Okazaki et al., Oncotarget (2018) 9:33832 S Sahdeo et al., Hum. Mol. Genet. (2014) 23:6848 D Ju et al., Int. J. Mol. Med. (2009) 23:205 D Ju & Y Xie, Mol. Med. Rep. (2014) 10:2609 |
Product Images
Chemical structure of Dyclonine HCl (SIH-638), a Neuroprotection . CAS #: 536-43-6. Molecular Formula: C18H27NO2 • HCl. Molecular Weight: 325.9 g/mol.
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