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| Product Name | Ebselen |
| Description |
Glutathione peroxidase mimic |
| Purity | >99% |
| CAS No. | 60940-34-3 |
| Molecular Formula | C13H9NOSe |
| Molecular Weight | 274.18 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO and 100% ethanol |
| Source | Synthetic |
| Appearance | Off-white Solid |
| SMILES | C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2 |
| InChI | InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H |
| InChIKey | DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful: May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: 23/25-33-50/53 Hazard Phrases: H301-H331-H373-H410 Precautionary Phrases: P261-P273-P301 + P310-P311-P501 |
| Cite This Product | Ebselen (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-204) |
Biological Description
| Alternative Names | 2-Phenyl-1,2-benzoselenazol-3(2H)-one |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 3194 |
| Scientific Background | Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite (1). It is being investigated as a possible treatment for reperfusion injury and stroke (2, 3), as well as tinnitus (4). Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides. |
| References |
1. Schewe T. (1995) Gen Pharmacol. 26(6): 1153-1169. 2. Parnham M., Seis H. (2000) Expert Opin Investig Drugs. 9(3): 607-619. 3. Yamaguchi T., et al. (1998) Stroke. 29(1): 12-17. 4. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. (2007) Hearing Research. 226(1-2): 44-51. |
Product Images
Chemical structure of Ebselen (SIH-204), a Glutathione peroxidase mimic. CAS #: 60940-34-3. Molecular Formula: C13H9NOSe. Molecular Weight: 274.18 g/mol.
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