FK-866 HCl

NAMPT Inhibitor

Catalog No. SIH-354

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CAS No. 658084-64-1
Molecular Formula C24H29N3O2•HCl
SKU: SIH-354 Categories: ,

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SIH-354_FK-866_HCl_Chemical_Structure.png
Product Name FK-866 HCl
Description

NAMPT Inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 658084-64-1
Molecular Formula C24H29N3O2•HCl
Molecular Weight 428
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 40 mg/ml Water
Source Synthetic
Appearance White Solid
SMILES C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC=CC=C3
InChI InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
InChIKey KPBNHDGDUADAGP-VAWYXSNFSA-N
Safety Phrases Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed.
Cite This Product FK-866 HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-354)

Biological Description

Alternative Names (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide, FK866 hydrochloride hydrate, K22.175
Research Areas Cell Signaling
PubChem ID 6914657
Scientific Background FK-866 HCl is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme involved in NAD⁺ biosynthesis. In neuroscience, FK-866 is used to study the role of NAD⁺ metabolism in neuronal survival, energy homeostasis, and neuroinflammation. NAD⁺ depletion induced by FK-866 leads to mitochondrial dysfunction and cell death, providing a model for investigating neurodegenerative mechanisms. Its application extends to exploring therapeutic strategies that target metabolic resilience and oxidative stress in neurodegenerative diseases.
References 1. Hasmann M., et al. (2003) Cancer Res. 63: 7436.
2. van der Veer E., et al. (2007) J. Biol. Chem. 282: 10841.

Product Images

<p>Chemical structure of FK-866 HCl (SIH-354), a NAD biosynth inhib. (SIR down regulator). CAS #: 658084-64-1. Molecular Formula: C24H29N3O2.HCl. Molecular Weight: 428 g/mol.</p>

Chemical structure of FK-866 HCl (SIH-354), a NAD biosynth inhib. (SIR down regulator). CAS #: 658084-64-1. Molecular Formula: C24H29N3O2.HCl. Molecular Weight: 428 g/mol.

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