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| Product Name | FK-866 HCl |
| Description |
NAMPT Inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 658084-64-1 |
| Molecular Formula | C24H29N3O2•HCl |
| Molecular Weight | 428 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 40 mg/ml Water |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC=CC=C3 |
| InChI | InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+ |
| InChIKey | KPBNHDGDUADAGP-VAWYXSNFSA-N |
| Safety Phrases |
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed. |
| Cite This Product | FK-866 HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-354) |
Biological Description
| Alternative Names | (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide, FK866 hydrochloride hydrate, K22.175 |
| Research Areas | Cell Signaling |
| PubChem ID | 6914657 |
| Scientific Background | FK-866 HCl is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme involved in NAD⁺ biosynthesis. In neuroscience, FK-866 is used to study the role of NAD⁺ metabolism in neuronal survival, energy homeostasis, and neuroinflammation. NAD⁺ depletion induced by FK-866 leads to mitochondrial dysfunction and cell death, providing a model for investigating neurodegenerative mechanisms. Its application extends to exploring therapeutic strategies that target metabolic resilience and oxidative stress in neurodegenerative diseases. |
| References |
1. Hasmann M., et al. (2003) Cancer Res. 63: 7436. 2. van der Veer E., et al. (2007) J. Biol. Chem. 282: 10841. |
Product Images
Chemical structure of FK-866 HCl (SIH-354), a NAD biosynth inhib. (SIR down regulator). CAS #: 658084-64-1. Molecular Formula: C24H29N3O2.HCl. Molecular Weight: 428 g/mol.
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